2014
High fat, high sucrose diet causes cardiac mitochondrial dysfunction due in part to oxidative post-translational modification of mitochondrial complex II
Sverdlov AL, Elezaby A, Behring JB, Bachschmid MM, Luptak I, Tu VH, Siwik DA, Miller EJ, Liesa M, Shirihai OS, Pimentel DR, Cohen RA, Colucci WS. High fat, high sucrose diet causes cardiac mitochondrial dysfunction due in part to oxidative post-translational modification of mitochondrial complex II. Journal Of Molecular And Cellular Cardiology 2014, 78: 165-173. PMID: 25109264, PMCID: PMC4268348, DOI: 10.1016/j.yjmcc.2014.07.018.Peer-Reviewed Original ResearchConceptsCysteine oxidative post-translational modificationsOxidative post-translational modificationsCardiac mitochondrial proteinsPost-translational modificationsMetabolic heart diseaseMitochondrial proteinsATP synthesisMitochondrial dysfunctionBasic Mitochondrial BiologyCardiac mitochondriaMitochondrial biologyOxidative stressTag labelingCardiac mitochondrial dysfunctionBiotin switchSubunit AATP productionMitochondrial ROSGSH/GSSG ratioFunctional consequencesMitochondriaReversible oxidationGSSG ratioProteinSDHA
1989
Determinants of glutathione efflux and biliary GSH/GSSG ratio in perfused rat liver
Ballatori N, Truong A, K. A, Boyer J. Determinants of glutathione efflux and biliary GSH/GSSG ratio in perfused rat liver. American Journal Of Physiology 1989, 256: g482-g490. PMID: 2564253, DOI: 10.1152/ajpgi.1989.256.3.g482.Peer-Reviewed Original ResearchConceptsGamma-glutamyl transferase activityO2 deliveryBiliary glutathioneHepatic effluxSinusoidal effluxKrebs-Ringer bicarbonate bufferGlutathione effluxRat liverEfflux of glutathioneGSH/GSSG ratioRed blood cellsPerfusion flow rateFluorocarbon emulsionsBile flowTissue GSHOxygen deliveryTransferase activityAT-125LiverBovine red blood cellsPerfusate compositionBlood cellsBileGSSG levelsGSSG ratio
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