2025
The Flagellin‐Specific Chaperone FliS of Borrelia burgdorferi Controls the Cytoplasmic Pool of Flagellins at the Level of Translation Initiation, Secretion, and Proteolysis
Sze C, Zhang K, Lynch M, Guo W, Liu J, Crane B, Li C. The Flagellin‐Specific Chaperone FliS of Borrelia burgdorferi Controls the Cytoplasmic Pool of Flagellins at the Level of Translation Initiation, Secretion, and Proteolysis. Molecular Microbiology 2025 PMID: 40491023, DOI: 10.1111/mmi.15380.Peer-Reviewed Original ResearchFlagellar assemblyRNA-binding protein CsrALevel of translation initiationNon-motile mutantPartner-switching mechanismPost-transcriptional regulatory mechanismsLyme disease spirochete Borrelia burgdorferiGroup of bacteriaLoss-of-function studiesCryo-electron tomographyFlagellar biosynthesisFlagellin proteinTranslation initiationTranscriptional cascadeRegulatory circuitsFlagellar filamentsCytoplasmic poolFliSInternal flagellaCytoplasmic accumulationRegulatory mechanismsCryo-electronFlaBSpirochete Borrelia burgdorferiFliW
2023
ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m6A modification-mediated RNA stability control
Gao Y, Zimmer J, Vasic R, Liu C, Gbyli R, Zheng S, Patel A, Liu W, Qi Z, Li Y, Nelakanti R, Song Y, Biancon G, Xiao A, Slavoff S, Kibbey R, Flavell R, Simon M, Tebaldi T, Li H, Halene S. ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m6A modification-mediated RNA stability control. Cell Reports 2023, 42: 113163. PMID: 37742191, PMCID: PMC10636609, DOI: 10.1016/j.celrep.2023.113163.Peer-Reviewed Original ResearchConceptsAlkB homolog 5Post-transcriptional regulatory mechanismsHematopoietic stemNumerous cellular processesProgenitor cell fitnessEnergy metabolismMitochondrial ATP productionMethyladenosine (m<sup>6</sup>A) RNA modificationTricarboxylic acid cycleCell energy metabolismHuman hematopoietic cellsMitochondrial energy productionCell fitnessCellular processesRNA modificationsRNA methylationRegulatory mechanismsEnzyme transcriptsATP productionHomolog 5Acid cycleΑ-ketoglutarateHematopoietic cellsMessenger RNAΑ-KG
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