Native Top-down analysis of membrane protein complexes directly from in vitro and native membranes
Jung W, Panda A, Lee J, Ghosh S, Shaw J, Gupta K. Native Top-down analysis of membrane protein complexes directly from in vitro and native membranes. Molecular & Cellular Proteomics 2025, 100993. PMID: 40378922, DOI: 10.1016/j.mcpro.2025.100993.Peer-Reviewed Original ResearchNative mass spectrometryProtein complexesMembrane proteinsBAM complexTop-down MS/MSAnalysis of membrane protein complexesMembrane-associated protein complexesTarget membrane proteinsNative membranesIntegral membrane proteinsTop-down identificationMembrane protein complexesCell-derived membrane vesiclesMass spectrometryMembrane vesiclesOrganization of proteinsDestabilize lipid bilayersAntibiotic targetsProtein-lipid complexesHeteromeric natureSynthetic liposomesCellular membranesCo-factorNative membrane vesiclesTotal membranes
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