2021
Lower Ventromedial Prefrontal Cortex Glutamate Levels in Patients With Obsessive–Compulsive Disorder
Batistuzzo M, Sottili B, Shavitt R, Lopes A, Cappi C, de Mathis M, Pastorello B, Diniz J, Silva R, Miguel E, Hoexter M, Otaduy M. Lower Ventromedial Prefrontal Cortex Glutamate Levels in Patients With Obsessive–Compulsive Disorder. Frontiers In Psychiatry 2021, 12: 668304. PMID: 34168581, PMCID: PMC8218991, DOI: 10.3389/fpsyt.2021.668304.Peer-Reviewed Original ResearchGamma-aminobutyric acidObsessive-compulsive disorderClinical symptomsHealthy controlsExcitatory/inhibitory imbalancePathophysiology of OCDGlu/Gln ratioH-MRS studiesGray matter fractionGlu/CrCortico-striatal circuitsGlutamate levelsExcitatory neurotransmissionNeurochemical imbalanceInhibitory imbalanceStriatal regionsUnderlying neurochemistryN-acetylaspartatePatientsKey neurotransmitterH-MRSVentromedial prefrontal cortexSecondary analysisAbnormal levelsPrefrontal cortex
2017
Cortical β-amyloid burden, gray matter, and memory in adults at varying APOE ε4 risk for Alzheimer's disease
Mecca AP, Barcelos NM, Wang S, Brück A, Nabulsi N, Planeta-Wilson B, Nadelmann J, Benincasa AL, Ropchan J, Huang Y, Gelernter J, Van Ness PH, Carson RE, van Dyck CH. Cortical β-amyloid burden, gray matter, and memory in adults at varying APOE ε4 risk for Alzheimer's disease. Neurobiology Of Aging 2017, 61: 207-214. PMID: 29111487, PMCID: PMC5722236, DOI: 10.1016/j.neurobiolaging.2017.09.027.Peer-Reviewed Original ResearchConceptsΒ-amyloid burdenMiddle-aged individualsAβ burdenEpisodic memory performanceCognitive declineGM fractionCortical β-amyloid burdenBrain magnetic resonance imagingFirst-degree family historyCortical Aβ burdenGray matter fractionNormal middle-aged individualsSubsequent cognitive declineMagnetic resonance imagingPositron emission tomographyAPOE ε3ε3Cortical AβCerebral amyloidosisAPOE genotypeFamily historyPreclinical ADMemory performanceNeuropsychological testingAlzheimer's diseaseGray matter
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