2000
Metabolism of Bradykinin In Vivo in Humans: Identification of BK1-5 as a Stable Plasma Peptide Metabolite 1 1 This study was supported by National Institutes of Health Grants HL56963, GM07569, DK48831, GM42056, GM15431, DK26657, CA68485, CA77839, and RR00095. J.D.M. is the recipient of a Burroughs Wellcome Fund Clinical Scientist Award in Translational Research.
Murphey LJ, Hachey DL, Oates JA, Morrow JD, Brown NJ. Metabolism of Bradykinin In Vivo in Humans: Identification of BK1-5 as a Stable Plasma Peptide Metabolite 1 1 This study was supported by National Institutes of Health Grants HL56963, GM07569, DK48831, GM42056, GM15431, DK26657, CA68485, CA77839, and RR00095. J.D.M. is the recipient of a Burroughs Wellcome Fund Clinical Scientist Award in Translational Research. Journal Of Pharmacology And Experimental Therapeutics 2000, 294: 263-269. PMID: 10871321, DOI: 10.1016/s0022-3565(24)39065-2.Peer-Reviewed Original ResearchConceptsBK1-5Stable metaboliteRole of bradykininMetabolism of bradykininDose of bradykininInfused bradykininBradykinin infusionVenous plasmaExogenous bradykininPlasma concentrationsPharmacologic alterationsSystemic circulationFmol/Total doseBradykinin generationPlasma metabolitesHuman volunteersBradykininDisease statesInfusionBloodDoseMetabolitesAmino acid fragmentHuman diseases
1996
Fourier transform infrared spectroscopy and site-directed isotope labeling as a probe of local secondary structure in the transmembrane domain of phospholamban
Ludlam C, Arkin I, Liu X, Rothman M, Rath P, Aimoto S, Smith S, Engelman D, Rothschild K. Fourier transform infrared spectroscopy and site-directed isotope labeling as a probe of local secondary structure in the transmembrane domain of phospholamban. Biophysical Journal 1996, 70: 1728-1736. PMID: 8785331, PMCID: PMC1225141, DOI: 10.1016/s0006-3495(96)79735-7.Peer-Reviewed Original ResearchConceptsSite-directed isotope labelingLocal secondary structureIsotope labelingSecondary structureSelective ion channelsTotal reflection Fourier transformPeptide amide groupsAmide IReflection Fourier transformDeuterium/hydrogen exchangeTransmembrane domainMembrane domainsMembrane proteinsTransmembrane orientationAmino acid fragmentSpectroscopic characterizationIon channelsHydrophobic regionAmide carbonylProtein backboneCardiac muscle cellsAmide groupLipid bilayersATPase activityFourier transform
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply