2018
Plasma Menthol Glucuronide as a Biomarker of Acute Menthol Inhalation
Jatlow P, Valentine G, Gueorguieva R, Nadim H, Wu R, O'Malley SS, Sofuoglu M. Plasma Menthol Glucuronide as a Biomarker of Acute Menthol Inhalation. Tobacco Regulatory Science 2018, 4: 586-591. PMID: 29479558, PMCID: PMC5822727, DOI: 10.18001/trs.4.1.5.Peer-Reviewed Original ResearchPlasma Mg concentrationHuman challenge studiesMenthol inhalationMenthol glucuronideMenthol exposureChallenge studiesAnti-irritant effectsDose-dependent increaseInhalation of aerosolsE-cigarette solutionsVenous plasmaVenous bloodIntravenous nicotineNicotine dependenceSecondary analysisInhalationE-cigarettesQuantitative biomarkersVulnerable populationsInter-individual differencesAfrican AmericansNicotineMenthol concentrationGlucuronideBiomarkers
2000
Metabolism of Bradykinin In Vivo in Humans: Identification of BK1-5 as a Stable Plasma Peptide Metabolite 1 1 This study was supported by National Institutes of Health Grants HL56963, GM07569, DK48831, GM42056, GM15431, DK26657, CA68485, CA77839, and RR00095. J.D.M. is the recipient of a Burroughs Wellcome Fund Clinical Scientist Award in Translational Research.
Murphey LJ, Hachey DL, Oates JA, Morrow JD, Brown NJ. Metabolism of Bradykinin In Vivo in Humans: Identification of BK1-5 as a Stable Plasma Peptide Metabolite 1 1 This study was supported by National Institutes of Health Grants HL56963, GM07569, DK48831, GM42056, GM15431, DK26657, CA68485, CA77839, and RR00095. J.D.M. is the recipient of a Burroughs Wellcome Fund Clinical Scientist Award in Translational Research. Journal Of Pharmacology And Experimental Therapeutics 2000, 294: 263-269. PMID: 10871321, DOI: 10.1016/s0022-3565(24)39065-2.Peer-Reviewed Original ResearchConceptsBK1-5Stable metaboliteRole of bradykininMetabolism of bradykininDose of bradykininInfused bradykininBradykinin infusionVenous plasmaExogenous bradykininPlasma concentrationsPharmacologic alterationsSystemic circulationFmol/Total doseBradykinin generationPlasma metabolitesHuman volunteersBradykininDisease statesInfusionBloodDoseMetabolitesAmino acid fragmentHuman diseases
1994
Effect of insulin on rat heart and skeletal muscle phenylalanyl-tRNA labeling and protein synthesis in vivo
Young LH, Stirewalt W, McNulty PH, Revkin JH, Barrett EJ. Effect of insulin on rat heart and skeletal muscle phenylalanyl-tRNA labeling and protein synthesis in vivo. American Journal Of Physiology 1994, 267: e337-e342. PMID: 8074214, DOI: 10.1152/ajpendo.1994.267.2.e337.Peer-Reviewed Original ResearchConceptsMuscle protein synthesisAcid-soluble poolFemoral venous plasmaSkeletal muscleSkeletal muscle protein synthesisEffect of insulinMuscle protein hydrolysateProtein synthesisContinuous infusionVenous plasmaHyperinsulinemic clampSaline infusionAnesthetized ratsArterial plasmaRat heartInsulin effectInsulinHormonal regulationHeartInfusionMuscleSpecific activityMinVivo measurementsLabeling
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