2015
Gene Expression Evolves under a House-of-Cards Model of Stabilizing Selection
Hodgins-Davis A, Rice DP, Townsend JP. Gene Expression Evolves under a House-of-Cards Model of Stabilizing Selection. Molecular Biology And Evolution 2015, 32: 2130-2140. PMID: 25901014, PMCID: PMC4592357, DOI: 10.1093/molbev/msv094.Peer-Reviewed Original ResearchConceptsGene expression evolvesGene expressionPhenotypic evolutionGenetic architectureExpression evolvesEvolutionary quantitative genetic modelsMutation accumulation linesNatural genetic variationStrength of selectionGenomic mutation rateQuantitative genetic modelGenomic data setsGene expression levelsEffects of selectionEvolutionary timeRegulatory evolutionStabilizing selectionAccumulation linesGene regulationMost genesNatural selectionGenetic variationMutational effectsFruit flyPhenotype space
2005
Widespread genetic exchange among terrestrial bacteriophages
Silander OK, Weinreich DM, Wright KM, O'Keefe KJ, Rang CU, Turner PE, Chao L. Widespread genetic exchange among terrestrial bacteriophages. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 19009-19014. PMID: 16365305, PMCID: PMC1323146, DOI: 10.1073/pnas.0503074102.Peer-Reviewed Original ResearchConceptsGenetic exchangeLinkage disequilibriumBiological species conceptWidespread genetic exchangeGenomic mutation rateFrequent genetic reassortmentSingle host cellGroup of phagesBiogeography studiesSexual populationsGenetic structureSpecies conceptWild populationsNucleotide divergenceFrequent reassortmentDsRNA genomeBacteriophage populationsDegenerate sitesRecombination eventsNumerical dominanceMutation rateHost cellsGenetic reassortmentUnrelated individualsBacteriophages
2001
Epistasis and the Mutation Load: A Measurement-Theoretical Approach
Hansen T, Wagner G. Epistasis and the Mutation Load: A Measurement-Theoretical Approach. Genetics 2001, 158: 477-485. PMID: 11333254, PMCID: PMC1461645, DOI: 10.1093/genetics/158.1.477.Peer-Reviewed Original ResearchConceptsMutation-selection equilibriumGene interactionsEpistatic interactionsMutation loadStrength of epistasisMutation-selection balanceGenomic mutation rateHigher-order gene interactionsSynergistic epistasisMean fitnessOptimal genotypeEpistatic effectsTwofold disadvantageEpistasisMutation rateGenetic backgroundSynergistic interactionSystematic relationshipGenesLociInteraction intensityInteractionFitnessInteraction densityGenotypes
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