A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A
Lane J, McLaren P, Dorrell L, Shianna K, Stemke A, Pelak K, Moore S, Oldenburg J, Alvarez-Roman M, Angelillo-Scherrer A, Boehlen F, Bolton-Maggs P, Brand B, Brown D, Chiang E, Cid-Haro A, Clotet B, Collins P, Colombo S, Dalmau J, Fogarty P, Giangrande P, Gringeri A, Iyer R, Katsarou O, Kempton C, Kuriakose P, Lin J, Makris M, Manco-Johnson M, Tsakiris D, Martinez-Picado J, Mauser-Bunschoten E, Neff A, Oka S, Oyesiku L, Parra R, Peter-Salonen K, Powell J, Recht M, Shapiro A, Stine K, Talks K, Telenti A, Wilde J, Yee T, Wolinsky S, Martinson J, Hussain S, Bream J, Jacobson L, Carrington M, Goedert J, Haynes B, McMichael A, Goldstein D, Fellay J, Immunology F. A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A. Human Molecular Genetics 2013, 22: 1903-1910. PMID: 23372042, PMCID: PMC3613165, DOI: 10.1093/hmg/ddt033.Peer-Reviewed Original ResearchMeSH KeywordsAdultDisease ResistanceDNA Copy Number VariationsEpistasis, GeneticFactor VIIIFemaleGene DeletionGenetic Predisposition to DiseaseGenome-Wide Association StudyHemophilia AHeterozygoteHIV InfectionsHIV SeropositivityHomozygoteHumansLogistic ModelsMaleMeta-Analysis as TopicMiddle AgedPhenotypePolymorphism, Single NucleotideProspective StudiesReceptors, CCR5ConceptsGenome-wide association studiesCopy number variantsSingle nucleotide polymorphismsFactor VIII infusionsHemophilia treatment centersAssociation studiesHost resistance factorsGenetic variantsSingle nucleotide polymorphism imputationGenome-wide genetic variantsHemophilia AHIV-1Genome-wide significanceIntroduction of viral inactivation proceduresGenome-wide approachesHuman genetic variationSusceptibility to HIV-1 infectionResistance to HIV infectionHIV-uninfected casesPathway enrichment analysisHIV-1 infectionHIV-1 susceptibilityHIV-infected controlsHIV-infected individualsHIV-1 serostatus
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