2025
A compendium of human gene functions derived from evolutionary modelling
Ramsey J, Siegele D, Chisholm R, Fey P, Giglio M, Nadendla S, Antonazzo G, Attrill H, Brown N, Garapati P, Marygold S, Ahmed S, Asanitthong P, Buitrago D, Erdol M, Gage M, Huang S, Kadhum M, Li K, Long M, Michalak A, Pesala A, Pritazahra A, Saverimuttu S, Su R, Xu Q, Lovering R, Blake J, Christie K, Corbani L, Dolan M, Ni L, Sitnikov D, Smith C, Lera-Ramirez M, Rutherford K, Wood V, D’Eustachio P, Demos W, De Pons J, Dwinell M, Hayman G, Kaldunski M, Kwitek A, Laulederkind S, Smith J, Tutaj M, Vedi M, Wang S, Engel S, Karra K, Miyasato S, Nash R, Skrzypek M, Weng S, Wong E, Achsel T, Andres-Alonso M, Bagni C, Bayés À, Biederer T, Brose N, Chua J, Coba M, Cornelisse L, de Juan-Sanz J, Goldschmidt H, Gundelfinger E, Huganir R, Imig C, Jahn R, Jung H, Kaeser P, Kim E, Koopmans F, Kreutz M, Lipstein N, MacGillavry H, McPherson P, O’Connor V, Pielot R, Ryan T, Sala C, Sheng M, Smalla K, Smit A, Toonen R, van Weering J, Verhage M, Verpelli C, Bakker E, Berardini T, Reiser L, Auchincloss A, Axelsen K, Argoud-Puy G, Blatter M, Boutet E, Breuza L, Bridge A, Casals-Casas C, Coudert E, Estreicher A, Famiglietti M, Gos A, Gruaz-Gumowski N, Hulo C, Hyka-Nouspikel N, Jungo F, Le Mercier P, Lieberherr D, Masson P, Morgat A, Pedruzzi I, Pourcel L, Poux S, Rivoire C, Sundaram S, Bowler-Barnett E, Bye-A-Jee H, Denny P, Ignatchenko A, Ishtiaq R, Lock A, Lussi Y, Magrane M, Martin M, Orchard S, Raposo P, Speretta E, Tyagi N, Warner K, Zaru R, Chan J, Diamantakis S, Raciti D, Fisher M, James-Zorn C, Ponferrada V, Zorn A, Ramachandran S, Ruzicka L, Westerfield M. A compendium of human gene functions derived from evolutionary modelling. Nature 2025, 640: 146-154. PMID: 40011791, PMCID: PMC11964926, DOI: 10.1038/s41586-025-08592-0.Peer-Reviewed Original ResearchHuman gene functionHuman protein-coding genesProtein-coding genesGene functionFunctional repertoireGene Ontology enrichment analysisGene Ontology ConsortiumOntology enrichment analysisHuman genomeHuman genesEvolutionary timeEvolutionary originGenomic techniquesEvolutionary modeling approachExpert-curatedEnrichment analysisGenesRegulatory functionsFunctional characteristicsEvolutionary modelsBiomedical researchGenomeRepertoireOrganisms1,2Body of information
2004
Flytrap, a database documenting a GFP protein‐trap insertion screen in Drosophila melanogaster
Kelso RJ, Buszczak M, Quiñones AT, Castiblanco C, Mazzalupo S, Cooley L. Flytrap, a database documenting a GFP protein‐trap insertion screen in Drosophila melanogaster. Nucleic Acids Research 2004, 32: d418-d420. PMID: 14681446, PMCID: PMC308749, DOI: 10.1093/nar/gkh014.Peer-Reviewed Original ResearchConceptsProtein localizationInsertion linesDrosophila melanogasterGFP fusion proteinTransposable element insertionsCellular component ontologyGene Ontology ConsortiumTransposable P elementsInverse PCR productsGene intronsArtificial exonElement insertionsGenomic DNAFusion proteinFlytrapMelanogasterComponent ontologyP elementsStages of developmentType of tissueLocalizationFlyBaseIntronsExonsGenes
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