Effects of histone methyltransferase inhibition in endometriosis†
Colón-Caraballo M, Torres-Reverón A, Soto-Vargas J, Young S, Lessey B, Mendoza A, Urrutia R, Flores I. Effects of histone methyltransferase inhibition in endometriosis†. Biology Of Reproduction 2018, 99: 293-307. PMID: 29408993, PMCID: PMC6373837, DOI: 10.1093/biolre/ioy030.Peer-Reviewed Original ResearchConceptsEndometriotic lesionsGene promoter regionEndometriotic cellsEndometriotic epithelial cellsPromoter regionInhibition of EZH2In vivo efficacyHistone methyltransferase EZH2Nonhormonal treatmentsImmunostaining levelsTissue microarrayEndometriotic tissueEutopic endometriumPreclinical studiesLevels of EZH2Invasion in vitroInvasion of endometriotic cellsGynecological diseasesEZH2 inhibitorsEZH2 protein levelsMethyltransferase inhibitionChromatin immunoprecipitation-qPCREpithelial cellsPharmacological inhibitionPharmacological inhibitors
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