2023
High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways
Mendes H, Neelakantan U, Liu Y, Fitzpatrick S, Chen T, Wu W, Pruitt A, Jin D, Jamadagni P, Carlson M, Lacadie C, Enriquez K, Li N, Zhao D, Ijaz S, Sakai C, Szi C, Rooney B, Ghosh M, Nwabudike I, Gorodezky A, Chowdhury S, Zaheer M, McLaughlin S, Fernandez J, Wu J, Eilbott J, Vander Wyk B, Rihel J, Papademetris X, Wang Z, Hoffman E. High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways. Cell Reports 2023, 42: 112243. PMID: 36933215, PMCID: PMC10277173, DOI: 10.1016/j.celrep.2023.112243.Peer-Reviewed Original ResearchConceptsGene lossFunctional analysisHigh-throughput functional analysisZebrafish mutantsGene discoverySelect mutantsASD genesAutism genesKey pathwaysASD biologyBrain size differencesMutantsGenesSize differencesPathwayGlobal increaseRelevant mechanismsBiologyCentral challengeNeuroimmune dysfunctionRegionFunctionDiscoveryAutism spectrum disorder
2011
Gene Duplication and Loss in a MADS Box Gene Transcription Factor Circuit
Lee HL, Irish VF. Gene Duplication and Loss in a MADS Box Gene Transcription Factor Circuit. Molecular Biology And Evolution 2011, 28: 3367-3380. PMID: 21712469, DOI: 10.1093/molbev/msr169.Peer-Reviewed Original ResearchConceptsGene duplicatesCore eudicotsGene gainEuasterids IMADS-box transcription factor geneTranscription factor circuitsB-class genesTranscription factor genesBox transcription factor genesProtein-protein interactionsLoss eventsParalog evolutionEvolutionary divergenceGene duplicationGene lossGene paralogsParalogous lineagesSequence diversificationClass genesSuch genesFloral morphologyGene networksPhylogenetic analysisObligate heterodimersProtein interactions
2008
Structural and functional diversification in the teleost S100 family of calcium-binding proteins
Kraemer A, Saraiva L, Korsching S. Structural and functional diversification in the teleost S100 family of calcium-binding proteins. BMC Ecology And Evolution 2008, 8: 48. PMID: 18275604, PMCID: PMC2266712, DOI: 10.1186/1471-2148-8-48.Peer-Reviewed Original ResearchConceptsS100 genesS100 gene familyGene familyJawless fishEF-handPatterns of gene gainCartilaginous fishCalcium-binding proteinLocal gene duplicationS100 familyMammalian family membersCell typesCalcium-mediated signalingEF-hand calcium-binding proteinS100 family membersGenomic arrangementTeleost genomesIntron/exon bordersGene lossGene duplicationGene gainFunctional diversificationS100 subfamilyFamily membersEvolutionary origin
2004
Complete Genome Sequence of the Genetically Tractable Hydrogenotrophic Methanogen Methanococcus maripaludis
Hendrickson E, Kaul R, Zhou Y, Bovee D, Chapman P, Chung J, de Macario E, Dodsworth J, Gillett W, Graham D, Hackett M, Haydock A, Kang A, Land M, Levy R, Lie T, Major T, Moore B, Porat I, Palmeiri A, Rouse G, Saenphimmachak C, Söll D, Van Dien S, Wang T, Whitman W, Xia Q, Zhang Y, Larimer F, Olson M, Leigh J. Complete Genome Sequence of the Genetically Tractable Hydrogenotrophic Methanogen Methanococcus maripaludis. Journal Of Bacteriology 2004, 186: 6956-6969. PMID: 15466049, PMCID: PMC522202, DOI: 10.1128/jb.186.20.6956-6969.2004.Peer-Reviewed Original ResearchConceptsProtein-coding genesMethanocaldococcus jannaschiiGenome sequenceSingle circular chromosomeLateral gene transferSelenocysteine-containing proteinsSubunit of enzymeGene lossCircular chromosomeReplication initiationUnique ORFsIron-sulfur centersClose homologMethanococcus maripaludisRNase HIIM. maripaludisRNase HIMethanogenesis enzymesMass spectrometric identificationRedox functionAlanine racemaseAlanine dehydrogenaseGenesGene transferFull complement
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply