2022
Live-Cell Imaging Shows Uneven Segregation of Extrachromosomal DNA Elements and Transcriptionally Active Extrachromosomal DNA Hubs in Cancer
Yi E, Gujar A, Guthrie M, Kim H, Zhao D, Johnson K, Amin S, Costa M, Yu Q, Das S, Jillette N, Clow P, Cheng A, Verhaak R. Live-Cell Imaging Shows Uneven Segregation of Extrachromosomal DNA Elements and Transcriptionally Active Extrachromosomal DNA Hubs in Cancer. Cancer Discovery 2022, 12: 468-483. PMID: 34819316, PMCID: PMC8831456, DOI: 10.1158/2159-8290.cd-21-1376.Peer-Reviewed Original ResearchConceptsExtrachromosomal DNA elementsDNA elementsUneven segregationRNA polymerase IILive-cell imagingPolymerase IIOffspring cellsGene transcriptionCell line modelsEcDNAsRandom segregationGenetic materialLiving cellsCopy numberLive cellsIndividual cellsTumor evolutionMitosisInheritance patternBreakpoint sequencesIssue featureTranscriptionFluorescent markersPatient tissuesCells
2011
PALM and STORM: Unlocking live‐cell super‐resolution
Henriques R, Griffiths C, Rego E, Mhlanga M. PALM and STORM: Unlocking live‐cell super‐resolution. Biopolymers 2011, 95: 322-331. PMID: 21254001, DOI: 10.1002/bip.21586.ChaptersConceptsLive-cell imaging approachesFluorescence light microscopySuper-resolution microscopySingle-molecule levelCellular biologyLocalization microscopy methodsLight microscopySuper-resolution imagingSingle-molecule localization microscopy methodsBiologyMolecule levelFluorescent markersRecent breakthroughsRecent advancesMicroscopy methodsLight microscopeImaging approachDynamic interactionMolecular visualizationPalmImportant toolCellsMicroscopyImportant goalMarkers
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