2022
Derivation and Validation of a Model to Predict Clinically Significant Portal Hypertension Using Transient Elastography and FIB-4
Banini BA, Patel S, Yu JW, Kang L, Bailey C, Strife BJ, Siddiqui MS, Patel V, Matherly SC, Lee H, Lewis S, Cherian R, Stravitz RT, Luketic V, Sanyal AJ, Sterling RK. Derivation and Validation of a Model to Predict Clinically Significant Portal Hypertension Using Transient Elastography and FIB-4. Journal Of Clinical Gastroenterology 2022, 57: 189-197. PMID: 34999644, PMCID: PMC9271129, DOI: 10.1097/mcg.0000000000001664.Peer-Reviewed Original ResearchConceptsHepatic venous pressure gradientSignificant portal hypertensionFIB-4Chronic liver diseaseAdvanced fibrosisPortal hypertensionLiver biopsyLiver diseasePlatelet countPositive predictive value 27Negative predictive value 99Venous pressure gradientTransjugular liver biopsyGold standardInternal bootstrap validationExternal validationLiver histologyFibrosis indexCurrent gold standardTransient elastographyOptimal cutoffBootstrap validationPatientsSpecificity 67Value 99
2020
Liver Fibrosis Indices and Outcomes After Primary Intracerebral Hemorrhage
Parikh NS, Kamel H, Navi BB, Iadecola C, Merkler AE, Jesudian A, Dawson J, Falcone GJ, Sheth KN, Roh DJ, Elkind MSV, Hanley DF, Ziai WC, Murthy SB, Hanley D, Butcher K, Davis S, Gregson B, Lees K, Lyden P, Mayer S, Muir K, Steiner T. Liver Fibrosis Indices and Outcomes After Primary Intracerebral Hemorrhage. Stroke 2020, 51: 830-837. PMID: 31906832, PMCID: PMC7048169, DOI: 10.1161/strokeaha.119.028161.Peer-Reviewed Original ResearchConceptsPrimary intracerebral hemorrhageNonalcoholic fatty liver disease fibrosis scoreAspartate aminotransferase-platelet ratio indexAminotransferase-platelet ratio indexLiver fibrosis indexIntracerebral hemorrhageAdmission hematoma volumeHematoma volumeHematoma expansionFibrosis-4Fibrosis indexFibrosis scoreLiver diseaseMajor disabilityRatio indexNormal liver chemistriesAdvanced liver diseaseFibrosis-4 scoreRetrospective cohort studyPlatelet ratio indexPoor stroke outcomesSubclinical liver diseaseLogistic regression modelsLiver chemistriesRadiological outcomes
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