2019
The Kappa Opioid Receptor Is Associated With Naltrexone-Induced Reduction of Drinking and Craving
de Laat B, Goldberg A, Shi J, Tetrault JM, Nabulsi N, Zheng MQ, Najafzadeh S, Gao H, Kapinos M, Ropchan J, O'Malley SS, Huang Y, Morris ED, Krishnan-Sarin S. The Kappa Opioid Receptor Is Associated With Naltrexone-Induced Reduction of Drinking and Craving. Biological Psychiatry 2019, 86: 864-871. PMID: 31399255, DOI: 10.1016/j.biopsych.2019.05.021.Peer-Reviewed Original ResearchConceptsKappa-opioid receptorsAlcohol use disorderOpioid receptorsUse disordersNonselective opioid receptor antagonistModest clinical effectsEfficacy of naltrexoneOpioid receptor antagonistDSM-IV criteriaPositron emission tomographyAlcohol Urge QuestionnaireNaltrexone initiationNaltrexone therapyClinical effectsReceptor antagonistTherapeutic effectCingulate cortexDrinking paradigmHeavy drinkersBilateral insulaNaltrexoneAlcohol dependenceBrain regionsEmission tomographyPrefrontal cortex
2017
2341
Vaughan C, Stangl B, Sinha R, Ramchandani V. 2341. Journal Of Clinical And Translational Science 2017, 1: 36-36. PMCID: PMC6798883, DOI: 10.1017/cts.2017.132.Peer-Reviewed Original ResearchChronic stressful eventsDrug Effects QuestionnaireNon-dependent drinkersAlcohol Urge QuestionnaireStress interviewStressful eventsChronic stressorsEarly life stress eventsBetter treatment outcomesChronic stress scoresAlcohol use disorderEarly life stressImpact of stressLife eventsRecent life eventsLife stress eventsImpaired Control ScaleMore chronic stressorsAlcohol infusionIntravenous alcoholTreatment outcomesPriming exposureLife Stress QuestionnaireUse disordersEffects Questionnaire2320
Brewton H, Stangl B, Kwako L, Sinha R, Ramchandani V. 2320. Journal Of Clinical And Translational Science 2017, 1: 35-35. PMCID: PMC6799609, DOI: 10.1017/cts.2017.129.Peer-Reviewed Original ResearchDrug Effects QuestionnaireBinge drinkersAlcohol Urge QuestionnaireACTH levelsACTH peakNonbinge drinkersAlcohol cuesHPA axis measuresSerial blood samplesHPA axis reactivityAdrenal axis markersAlcohol-dependent individualsACTH ratioBinge groupIntravenous alcoholAlcohol relapseBlood samplesAlcohol consumptionEffects QuestionnaireAlcohol cravingACTH changesDistress ScaleDrinkersSignificant predictorsNeutral scripts
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