2018
Patients with common variable immunodeficiency with autoimmune cytopenias exhibit hyperplastic yet inefficient germinal center responses
Romberg N, Le Coz C, Glauzy S, Schickel JN, Trofa M, Nolan BE, Paessler M, Xu M, Lambert MP, Lakhani SA, Khokha MK, Jyonouchi S, Heimall J, Takach P, Maglione PJ, Catanzaro J, Hsu FI, Sullivan KE, Cunningham-Rundles C, Meffre E. Patients with common variable immunodeficiency with autoimmune cytopenias exhibit hyperplastic yet inefficient germinal center responses. Journal Of Allergy And Clinical Immunology 2018, 143: 258-265. PMID: 29935219, PMCID: PMC6400323, DOI: 10.1016/j.jaci.2018.06.012.Peer-Reviewed Original ResearchConceptsCommon variable immunodeficiencyVariable immunodeficiencyB cellsCommensal bacteriaIsotype-switched memory B cellsRegulatory T cell frequencyFollicular helper T cellsGC responseIsotype-switched antibodiesT cell frequenciesSubset of patientsT cell compartmentHelper T cellsPeripheral blood samplesMemory B cellsGerminal center responseB cell clonesAutoimmune cytopeniasGC hyperplasiaSerum endotoxemiaExcisional lymphAntibody responseT cellsMucosal microbiotaSomatic hypermutation frequencies
2012
Multicentric Castleman Disease with Complete Duodenal Obstruction in an HIV Patient
Sethi T, Alireza A, Kloecker G, Slone S. Multicentric Castleman Disease with Complete Duodenal Obstruction in an HIV Patient. Blood 2012, 120: 4834. DOI: 10.1182/blood.v120.21.4834.4834.Peer-Reviewed Original ResearchMulticentric Castleman's diseaseBody cavity lymphomasComplete duodenal obstructionEbstein-Barr virusCastleman's diseaseDuodenal obstructionHigh plasma titersHHV-8Peripancreatic involvementExcisional lymphHIV patientsPlasma titersPET-CTMultiple myeloma oncogene 1Human herpes virus-8 (HHV-8) DNASetting of HIVUse of HAARTBilateral pleural effusionPancreatic head massMesenteric lymph nodesPlasma cell variantPleural fluid cytologyHistory of HIVEpithelial membrane antigenFine-needle aspiration
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