2011
Modulation of β-Adrenergic Receptors in the Ventromedial Hypothalamus Influences Counterregulatory Responses to Hypoglycemia
Szepietowska B, Zhu W, Chan O, Horblitt A, Dziura J, Sherwin RS. Modulation of β-Adrenergic Receptors in the Ventromedial Hypothalamus Influences Counterregulatory Responses to Hypoglycemia. Diabetes 2011, 60: 3154-3158. PMID: 22013013, PMCID: PMC3219955, DOI: 10.2337/db11-0432.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-2 Receptor AgonistsAdrenergic beta-AntagonistsAnimalsBlood GlucoseEpinephrineEthanolaminesFormoterol FumarateGlucagonGlucose Clamp TechniqueHypoglycemiaImidazolesInsulinMaleNorepinephrinePropanolaminesRatsRats, Sprague-DawleyReceptors, Adrenergic, betaVentromedial Hypothalamic NucleusConceptsCounterregulatory responsesVentromedial hypothalamusGlucose counterregulationAwake male Sprague-Dawley ratsB2AR agonistMale Sprague-Dawley ratsCounterregulatory hormone releaseDefective glucose counterregulationExogenous glucose requirementsHyperinsulinemic-hypoglycemic clamp studySprague-Dawley ratsLocal catecholamine releaseArtificial extracellular fluidΒ-Adrenergic ReceptorsEpinephrine responseGlucagon responseDiabetic patientsEpinephrine releaseSimilar insulinCatecholamine releaseHormone releaseGuide cannulaeClamp studiesTherapeutic benefitHypoglycemia
2008
Increased GABAergic Tone in the Ventromedial Hypothalamus Contributes to Suppression of Counterregulatory Reponses After Antecedent Hypoglycemia
Chan O, Cheng H, Herzog R, Czyzyk D, Zhu W, Wang A, McCrimmon RJ, Seashore MR, Sherwin RS. Increased GABAergic Tone in the Ventromedial Hypothalamus Contributes to Suppression of Counterregulatory Reponses After Antecedent Hypoglycemia. Diabetes 2008, 57: 1363-1370. PMID: 18375441, PMCID: PMC5518793, DOI: 10.2337/db07-1559.Peer-Reviewed Original ResearchConceptsVMH GABA levelsVentromedial hypothalamusGlutamic acid decarboxylaseHypoglycemic animalsHypoglycemic ratsSympathoadrenal responseRecurrent hypoglycemiaCounterregulatory responsesGABAergic toneInhibitory toneGABA levelsHypoglycemia-associated autonomic failureGABAergic inhibitory toneOnset of hypoglycemiaGABA synthetic enzymeQuantitative RT-PCRAntecedent hypoglycemiaAutonomic failureHypoglycemic stimulusReceptor blockadeEpinephrine releaseAcute hypoglycemiaReceptor antagonistInhibitory neurotransmitterSubsequent bout
1993
Inhibitory Effect of Pregnancy on Counterregulatory Hormone Responses to Hypoglycemia in Awake Rat
Rossi G, Lapaczewski P, Diamond M, Jacob R, Shulman G, Sherwin R. Inhibitory Effect of Pregnancy on Counterregulatory Hormone Responses to Hypoglycemia in Awake Rat. Diabetes 1993, 42: 1440-1445. PMID: 8375583, DOI: 10.2337/diab.42.10.1440.Peer-Reviewed Original ResearchConceptsPregnant ratsGlucagon responseNonpregnant controlsAwake pregnant ratsCounterregulatory hormone responsesIntensive insulin treatmentRelease of epinephrineHypoglycemia risk factorsHypoglycemic clamp studiesDiabetic pregnanciesGlucose counterregulationMaternal hypoglycemiaHypoglycemic stimulusEpinephrine releaseEpinephrine levelsMild hypoglycemiaBrisk responseNonfasting stateRisk factorsAwake ratsInsulin treatmentKetone levelsClamp studiesGlucose levelsNonfasted state
1992
Impaired stimulation of gluconeogenesis during prolonged hypoglycemia in intensively treated insulin-dependent diabetic subjects
Caprio S, Napoli R, Saccà L, Tamborlane WV, Sherwin RS. Impaired stimulation of gluconeogenesis during prolonged hypoglycemia in intensively treated insulin-dependent diabetic subjects. The Journal Of Clinical Endocrinology & Metabolism 1992, 75: 1076-1080. PMID: 1400874, DOI: 10.1210/jcem.75.4.1400874.Peer-Reviewed Original ResearchConceptsType I diabetic subjectsHepatic glucose productionDiabetic subjectsGlucose productionControl subjectsInsulin-dependent diabetic subjectsDefective glucose counterregulationFailure of gluconeogenesisLow-dose infusionInsulin-induced hypoglycemiaInsulin-dependent diabetesNormal control subjectsGlucagon responseGlucose counterregulationIDDM patientsIDDM subjectsDose infusionEpinephrine releaseInsulin levelsPlasma glucoseImpaired stimulationConversion of alanineNormal subjectsCompensatory stimulationHepatic response
1991
Independent Effects of Youth and Poor Diabetes Control on Responses to Hypoglycemia in Children
Jones T, Boulware S, Kraemer D, Caprio S, Sherwin R, Tamborlane W. Independent Effects of Youth and Poor Diabetes Control on Responses to Hypoglycemia in Children. Diabetes 1991, 40: 358-363. PMID: 1999278, DOI: 10.2337/diab.40.3.358.Peer-Reviewed Original ResearchConceptsInsulin-dependent diabetes mellitusSymptom awarenessNondiabetic childrenPlasma glucoseGlucose thresholdHormone releaseGlucose levelsCounterregulatory hormone levelsCounterregulatory hormone releasePoor diabetes controlGlucose clamp techniqueGrowth hormone releasePlasma glucose levelsEffects of childhoodCounterregulatory hormonesEpinephrine responseNondiabetic adultsYounger patientsDiabetes mellitusEpinephrine releaseSymptom scoresDiabetes controlPlasma epinephrineSymptomatic responseMild hypoglycemia
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