2016
Epicutaneous immunization with ovalbumin and CpG induces TH1/TH17 cytokines, which regulate IgE and IgG2a production
Majewska-Szczepanik M, Askenase PW, Lobo FM, Marcińska K, Wen L, Szczepanik M. Epicutaneous immunization with ovalbumin and CpG induces TH1/TH17 cytokines, which regulate IgE and IgG2a production. Journal Of Allergy And Clinical Immunology 2016, 138: 262-273.e6. PMID: 26810716, PMCID: PMC5278675, DOI: 10.1016/j.jaci.2015.11.018.Peer-Reviewed Original ResearchConceptsSubcutaneous allergen-specific immunotherapyOVA-specific IgEEpicutaneous immunizationAllergen-specific immunotherapyAntigen-specific mannerT cell receptorAllergic diseasesToll-like receptor 9 agonistMyeloid differentiation primary response 88Differentiation primary response 88Course of allergyIL-17A dependentTolerability of immunotherapyLong-term remissionTH1/TH17 cytokinesReceptor 9 agonistAdoptive cell transferEosinophil peroxidase activityEpicutaneous treatmentRegulatory cellsTh17 cytokinesAtopic dermatitisIL-10IgG2a productionIgE synthesis
2014
Epicutaneous Immunization with TNP-Ig and Zymosan Induces TCRαβ+ CD4+ Contrasuppressor Cells That Reverse Skin-Induced Suppression via IL-17A
Majewska-Szczepanik M, Strzepa A, Marcińska K, Wen L, Szczepanik M. Epicutaneous Immunization with TNP-Ig and Zymosan Induces TCRαβ+ CD4+ Contrasuppressor Cells That Reverse Skin-Induced Suppression via IL-17A. International Archives Of Allergy And Immunology 2014, 164: 122-136. PMID: 24993442, PMCID: PMC4141016, DOI: 10.1159/000363446.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, CutaneousAnimalsAntigensCD4-Positive T-LymphocytesDermatitis, ContactHaptensImmunity, InnateImmunizationImmunoglobulinsImmunosuppression TherapyInterleukin-17Lymph NodesMiceMice, Inbred C57BLMice, Inbred CBAMyeloid Differentiation Factor 88Receptors, Antigen, T-Cell, alpha-betaSkinToll-Like Receptor 2Transforming Growth Factor betaTrinitrobenzenesVaccinationZymosanConceptsSkin-induced suppressionSuppression of CHSContact hypersensitivityEC immunizationEpicutaneous immunizationTNP-IgAdoptive cell transfer experimentsProtein antigensT contrasuppressor cellsT suppressor cellsLymph node cellsCell transfer experimentsCHS responseContrasuppressor cellsIL-17ASuppressor cellsCytokine productionNode cellsImmunogenic antigensPresence of zymosanAntigen E.ImmunizationInnate immunityCD4Gauze patches
2012
Epicutaneous immunization with DNP‐BSA induces CD4+ CD25+ Treg cells that inhibit Tc1‐mediated CS
Majewska‐Szczepanik M, Zemelka‐Wiącek M, Ptak W, Wen L, Szczepanik M. Epicutaneous immunization with DNP‐BSA induces CD4+ CD25+ Treg cells that inhibit Tc1‐mediated CS. Immunology And Cell Biology 2012, 90: 784-795. PMID: 22290507, DOI: 10.1038/icb.2012.1.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsCell CommunicationCell ProliferationCTLA-4 AntigenCytokinesDermatitis, ContactDinitrophenolsDose-Response Relationship, ImmunologicFemaleForkhead Transcription FactorsImmunizationInflammationInflammation MediatorsInterleukin-2 Receptor alpha SubunitLymphoid TissueMiceMice, Inbred BALB CPhenotypeReceptors, Antigen, T-Cell, alpha-betaSerum Albumin, BovineSkinT-Lymphocytes, CytotoxicT-Lymphocytes, RegulatoryConceptsEC immunizationLymph nodesContact sensitivityTreg cellsDNP-BSAEffector T cell responsesRegulatory T cellsT cell responsesSubcutaneous lymph nodesEpicutaneous immunizationInduces CD4Subsequent unresponsivenessIL-12Normal miceT cellsCS responsesImmunizationTranswell systemInhibited productionFlow cytometryProtein antigensCell proliferationLymphocytesCell contactSensitization
2009
Epicutaneous Immunization with Protein Antigen in the Presence of TLR4 Ligand Induces TCRαβ+CD4+ T Contrasuppressor Cells That Reverse Skin-Induced Suppression of Th1-Mediated Contact Sensitivity
Ptak W, Majewska M, Bryniarski K, Ptak M, Lobo FM, Zając K, Askenase PW, Szczepanik M. Epicutaneous Immunization with Protein Antigen in the Presence of TLR4 Ligand Induces TCRαβ+CD4+ T Contrasuppressor Cells That Reverse Skin-Induced Suppression of Th1-Mediated Contact Sensitivity. The Journal Of Immunology 2009, 182: 837-850. PMID: 19124727, DOI: 10.4049/jimmunol.182.2.837.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, CutaneousAnimalsCD4-Positive T-LymphocytesCells, CulturedContraindicationsDermatitis, ContactImmune ToleranceImmunizationLigandsLipopolysaccharidesMaleMiceMice, Inbred BALB CMice, Inbred CBAMice, KnockoutMice, TransgenicPatch TestsReceptors, Antigen, T-Cell, alpha-betaSkinTh1 CellsToll-Like Receptor 4TrinitrobenzenesConceptsEpicutaneous immunizationEffector cellsIL-12Effector phaseT cellsIFN-gammaTC cellsContrasuppressor T cellsCS effector cellsIL-12 neutralizationSkin-induced suppressionContact sensitivity reactionTh1 effector cellsTLR4 ligand LPSMechanism of actionEC immunizationSuppressor CD4Th1 CD4Regulatory cellsRIL-12TLR4 ligandIL-6Contact sensitivityLigand LPSINF-gamma
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