2014
Epicutaneous Immunization with TNP-Ig and Zymosan Induces TCRαβ+ CD4+ Contrasuppressor Cells That Reverse Skin-Induced Suppression via IL-17A
Majewska-Szczepanik M, Strzepa A, Marcińska K, Wen L, Szczepanik M. Epicutaneous Immunization with TNP-Ig and Zymosan Induces TCRαβ+ CD4+ Contrasuppressor Cells That Reverse Skin-Induced Suppression via IL-17A. International Archives Of Allergy And Immunology 2014, 164: 122-136. PMID: 24993442, PMCID: PMC4141016, DOI: 10.1159/000363446.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, CutaneousAnimalsAntigensCD4-Positive T-LymphocytesDermatitis, ContactHaptensImmunity, InnateImmunizationImmunoglobulinsImmunosuppression TherapyInterleukin-17Lymph NodesMiceMice, Inbred C57BLMice, Inbred CBAMyeloid Differentiation Factor 88Receptors, Antigen, T-Cell, alpha-betaSkinToll-Like Receptor 2Transforming Growth Factor betaTrinitrobenzenesVaccinationZymosanConceptsSkin-induced suppressionSuppression of CHSContact hypersensitivityEC immunizationEpicutaneous immunizationTNP-IgAdoptive cell transfer experimentsProtein antigensT contrasuppressor cellsT suppressor cellsLymph node cellsCell transfer experimentsCHS responseContrasuppressor cellsIL-17ASuppressor cellsCytokine productionNode cellsImmunogenic antigensPresence of zymosanAntigen E.ImmunizationInnate immunityCD4Gauze patches
2009
Epicutaneous Immunization with Protein Antigen in the Presence of TLR4 Ligand Induces TCRαβ+CD4+ T Contrasuppressor Cells That Reverse Skin-Induced Suppression of Th1-Mediated Contact Sensitivity
Ptak W, Majewska M, Bryniarski K, Ptak M, Lobo FM, Zając K, Askenase PW, Szczepanik M. Epicutaneous Immunization with Protein Antigen in the Presence of TLR4 Ligand Induces TCRαβ+CD4+ T Contrasuppressor Cells That Reverse Skin-Induced Suppression of Th1-Mediated Contact Sensitivity. The Journal Of Immunology 2009, 182: 837-850. PMID: 19124727, DOI: 10.4049/jimmunol.182.2.837.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, CutaneousAnimalsCD4-Positive T-LymphocytesCells, CulturedContraindicationsDermatitis, ContactImmune ToleranceImmunizationLigandsLipopolysaccharidesMaleMiceMice, Inbred BALB CMice, Inbred CBAMice, KnockoutMice, TransgenicPatch TestsReceptors, Antigen, T-Cell, alpha-betaSkinTh1 CellsToll-Like Receptor 4TrinitrobenzenesConceptsEpicutaneous immunizationEffector cellsIL-12Effector phaseT cellsIFN-gammaTC cellsContrasuppressor T cellsCS effector cellsIL-12 neutralizationSkin-induced suppressionContact sensitivity reactionTh1 effector cellsTLR4 ligand LPSMechanism of actionEC immunizationSuppressor CD4Th1 CD4Regulatory cellsRIL-12TLR4 ligandIL-6Contact sensitivityLigand LPSINF-gamma
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