Proteomics Mapping of Cord Blood Identifies Haptoglobin “Switch-On” Pattern as Biomarker of Early-Onset Neonatal Sepsis in Preterm Newborns
Buhimschi CS, Bhandari V, Dulay AT, Nayeri UA, Abdel-Razeq SS, Pettker CM, Thung S, Zhao G, Han YW, Bizzarro M, Buhimschi IA. Proteomics Mapping of Cord Blood Identifies Haptoglobin “Switch-On” Pattern as Biomarker of Early-Onset Neonatal Sepsis in Preterm Newborns. PLOS ONE 2011, 6: e26111. PMID: 22028810, PMCID: PMC3189953, DOI: 10.1371/journal.pone.0026111.Peer-Reviewed Original ResearchConceptsEarly-onset neonatal sepsisCord bloodNeonatal outcomesNeonatal sepsisPreterm newbornsAdverse short-term neonatal outcomesShort-term neonatal outcomesSelection of newbornsIntra-amniotic infectionIntra-ventricular hemorrhageLatent class analysisEONS diagnosisAntenatal exposurePreterm birthProspective cohortPremature newbornsAdverse outcomesInterleukin-6Odds ratioProtein immunoreactivityTargeted treatmentTwo-dimensional differential gel electrophoresisElevated haptoglobinNewbornsImportant cause
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