Vitamin D mitigates the adverse effects of obesity on breast cancer in mice
Swami S, Krishnan A, Williams J, Aggarwal A, Albertelli M, Horst R, Feldman B, Feldman D. Vitamin D mitigates the adverse effects of obesity on breast cancer in mice. Endocrine Related Cancer 2016, 23: 251-264. PMID: 26817629, PMCID: PMC4889430, DOI: 10.1530/erc-15-0557.Peer-Reviewed Original ResearchMeSH KeywordsAdiponectinAdipose TissueAMP-Activated Protein KinasesAnimalsAromataseCalciumCyclooxygenase 2Diet, High-FatDietary SupplementsDinoprostoneEstradiolEstrogensEstroneFemaleHumansLeptinMammary Glands, AnimalMammary Neoplasms, ExperimentalMCF-7 CellsMiceMice, Inbred C57BLObesityOvariectomyRNA, MessengerTumor BurdenVitamin DConceptsAdverse effects of obesityDietary vitamin DEffect of obesityDiet-induced obesityBreast cancer growthVitamin DBreast cancerEstrogen synthesisAdverse effectsObese miceExpression of leptin receptorInsulin resistanceMMTV-Wnt1 transgenic miceIncreased adiponectin receptorsEstrogen receptor-positiveOvariectomized C57BL/6 micePostmenopausal breast cancerVitamin D deficiencyMultiple interrelated pathwaysMammary fat padLocal estrogen synthesisBreast tumor cellsSurrounding adipose tissuePostmenopausal settingVitamin D compounds
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