The pyranoxanthone inophyllin A induces oxidative stress mediated-apoptosis in Jurkat T lymphoblastic leukemia cells
Chan K, Hamzah R, Rahaman A, Jong V, Khong H, Rajab N, Ee G, Inayat-Hussain S. The pyranoxanthone inophyllin A induces oxidative stress mediated-apoptosis in Jurkat T lymphoblastic leukemia cells. Food And Chemical Toxicology 2012, 50: 2916-2922. PMID: 22613213, DOI: 10.1016/j.fct.2012.04.048.Peer-Reviewed Original ResearchConceptsJurkat T lymphoblastic leukemia cellsDNA damageReactive oxygen speciesCell deathJurkat cellsEarly apoptotic signalsMitochondrial membrane potentialLymphoblastic leukemia cellsTetramethylrhodamine ethyl esterLoss of MMPOxidative stressLeukemia cellsCaspase-2Apoptotic signalsPotential chemotherapeutic activityMolecular mechanismsInduces oxidative stressIntrinsic pathwayPhosphatidylserine exposureEarly oxidative stressCaspase-3Oxygen speciesMembrane potentialApoptosisFree thiols
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