2020
A glioneuronal tumor with CLIP2-MET fusion
Chowdhury T, Lee Y, Kim S, Yu H, Ji S, Bae J, Won J, Shin J, Weinberger D, Choi S, Park C, Kim J, Park S. A glioneuronal tumor with CLIP2-MET fusion. Npj Genomic Medicine 2020, 5: 24. PMID: 32550005, PMCID: PMC7270112, DOI: 10.1038/s41525-020-0131-6.Peer-Reviewed Original Research
2017
Immunohistochemical null-phenotype for mismatch repair proteins in colonic carcinoma associated with concurrent MLH1 hypermethylation and MSH2 somatic mutations
Wang T, Stadler Z, Zhang L, Weiser M, Basturk O, Hechtman J, Vakiani E, Saltz L, Klimstra D, Shia J. Immunohistochemical null-phenotype for mismatch repair proteins in colonic carcinoma associated with concurrent MLH1 hypermethylation and MSH2 somatic mutations. Familial Cancer 2017, 17: 225-228. PMID: 28819720, PMCID: PMC5908711, DOI: 10.1007/s10689-017-0031-9.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAged, 80 and overBiomarkers, TumorColonic NeoplasmsDNA MethylationDNA Mismatch RepairDNA-Binding ProteinsFemaleGene Expression Regulation, NeoplasticGerm-Line MutationHumansImmunohistochemistryMismatch Repair Endonuclease PMS2MutL Protein Homolog 1MutS Homolog 2 ProteinPhenotypeConceptsMismatch repair proteinsMismatch repairFamily cancer historyMLH1 methylation testingNext generation sequencingSomatic truncating mutationsMismatch repair protein immunohistochemistryCancer historyClinical management implicationsDNA mismatch repairGeneration sequencingNull phenotypeMLH1 hypermethylationTruncating mutationsDriver pathwaysRepair proteinsSomatic mutationsPromoter hypermethylationStaining patternMismatch repair deficiencyFamily membersProteinHereditary conditionSurveillance programColorectal carcinogenesis
2013
Integrative Genomic Characterization of Oral Squamous Cell Carcinoma Identifies Frequent Somatic Drivers
Pickering CR, Zhang J, Yoo SY, Bengtsson L, Moorthy S, Neskey DM, Zhao M, Alves M, Chang K, Drummond J, Cortez E, Xie TX, Zhang D, Chung W, Issa JP, Zweidler-McKay PA, Wu X, El-Naggar AK, Weinstein JN, Wang J, Muzny DM, Gibbs RA, Wheeler DA, Myers JN, Frederick MJ. Integrative Genomic Characterization of Oral Squamous Cell Carcinoma Identifies Frequent Somatic Drivers. Cancer Discovery 2013, 3: 770-781. PMID: 23619168, PMCID: PMC3858325, DOI: 10.1158/2159-8290.cd-12-0537.Peer-Reviewed Original ResearchConceptsOral squamous cell carcinomaCaspase-8Integrative Genomic CharacterizationGenomic alterationsSquamous cell carcinomaComprehensive genomic analysisTumor suppressor geneCopy number changesSomatic driversKey genesGenomic analysisCell carcinomaGene expressionNotch pathwayGenomic characterizationSuppressor geneDriver pathwaysCopy numberPoint mutationsGenesSomatic eventsNumber changesSurvival of patientsOSCC cell linesSubset of head
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply