2025
Hypothesizing glucagon-like peptide 1 (GLP-1), agonists promote hypodopaminergia, resulting in heightened addictive reward-seeking and altered mood: Breaking the bubble and adding salt to a wound
Blum K, Dennen C, Lewandrowski K, Sharafshah A, Pinhasov A, Bowirrat A, Elman I, Cadet J, Braverman E, Thanos P, Makale M, Baron D, Ashford J, Fuehrlein B, Avena N, Gardner E, Badgaiyan R, Gondré—Lewis M, Modestino E, Khalsa J, Murphy K, Sunder K, Foojan Z, Jafari N, Carney P, Cortes R, Edwards D, Roy A, Smith D, Gold M. Hypothesizing glucagon-like peptide 1 (GLP-1), agonists promote hypodopaminergia, resulting in heightened addictive reward-seeking and altered mood: Breaking the bubble and adding salt to a wound. Medical Hypotheses 2025, 198: 111612. DOI: 10.1016/j.mehy.2025.111612.Peer-Reviewed Original ResearchReceptor agonistsGLP-1 receptor agonistsUse disorderGABA neuronsActivation of VTA GABA neuronsActivity of VTA dopamine neuronsIn vivo fiber photometryAttenuated cocaine seekingVTA dopamine neuronsVTA GABA neuronsReward-seeking behaviorAssociated with increased activityDopaminergic reward pathwayAlcohol use disorderSubstance use disordersGLP-1Cocaine seekingFluorescence in situ hybridizationReward-seekingReward pathwayAntiaddictive propertiesDopamine signalingDopaminergic pathwaysDopamine neuronsFiber photometry
2012
Relation between changes in neural responsivity and reductions in desire to eat high-calorie foods following gastric bypass surgery
Ochner C, Stice E, Hutchins E, Afifi L, Geliebter A, Hirsch J, Teixeira J. Relation between changes in neural responsivity and reductions in desire to eat high-calorie foods following gastric bypass surgery. Neuroscience 2012, 209: 128-135. PMID: 22406414, PMCID: PMC3601838, DOI: 10.1016/j.neuroscience.2012.02.030.Peer-Reviewed Original ResearchConceptsLow-calorie food cuesGastric bypass surgeryPostoperative reductionPostoperative changesHigh-calorie foodsBypass surgeryNeural responsivityFood cuesSignificant postoperative reductionReward-related neural activationFunctional magnetic resonance imagingMagnetic resonance imagingDopaminergic reward pathwayLow-calorie foodsObesity surgeryLiking of foodNeural changesReward pathwayResonance imagingOne monthSurgeryRating ScaleInhibitory activationNeural activationRYGB
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply