2024
Immunotherapy for Resectable Locally Advanced Esophageal Carcinoma
Fick C, Dunne E, Sihag S, Molena D, Cytryn S, Janjigian Y, Wu A, Worrell S, Hofstetter W, Jones D, Gray K. Immunotherapy for Resectable Locally Advanced Esophageal Carcinoma. The Annals Of Thoracic Surgery 2024, 118: 130-140. PMID: 38408631, PMCID: PMC11194153, DOI: 10.1016/j.athoracsur.2024.02.021.Peer-Reviewed Original ResearchLocally advanced esophagealImmune checkpoint inhibitorsDisease-free survivalGastroesophageal junctionPerioperative immunotherapyAdvanced esophagealNeoadjuvant chemoradiotherapyEsophageal carcinomaLocally advanced esophageal carcinomaPooled adverse event rateLocally advanced esophageal cancerPathologic complete response rateResponse rateDual checkpoint inhibitionGastroesophageal junction carcinomaAdvanced esophageal carcinomaComplete response rateAdvanced esophageal cancerEsophageal squamous cell carcinomaGastroesophageal junction cancerR0 resection rateResectable esophageal carcinomaPhase III trialsSquamous cell carcinomaAdverse event rates
2023
Pre-operative chemoradiotherapy with or without induction chemotherapy for operable locally-advanced esophageal cancer
Peters G, Talcott W, Peters N, Dhanasopan A, Lacy J, Cecchini M, Kortmansky J, Stein S, Lattanzi S, Park H, Boffa D, Johung K, Jethwa K. Pre-operative chemoradiotherapy with or without induction chemotherapy for operable locally-advanced esophageal cancer. Journal Of Gastrointestinal Oncology 2023, 14: 1181-1192. PMID: 37435226, PMCID: PMC10331751, DOI: 10.21037/jgo-22-1005.Peer-Reviewed Original ResearchProgression-free survivalMedian progression-free survivalOverall survivalIC-CRTInduction chemotherapySingle-institution retrospective cohort studyPre-operative chemoradiotherapyAdvanced esophageal cancerAdvanced esophageal carcinomaPathologic complete responseRetrospective cohort studyKaplan-Meier methodSubset of patientsProportional hazards regressionCycles of inductionAdenocarcinoma histologyCRT cohortCohort studyComplete responsePathologic responseTreatment cohortsDistant metastasisHazards regressionEsophageal cancerEsophageal carcinomaPaclitaxel With or Without Cixutumumab as Second-Line Treatment of Metastatic Esophageal or Gastroesophageal Junction Cancer: A Randomized Phase II ECOG-ACRIN Trial
Stockton S, Catalano P, Cohen S, Burtness B, Mitchell E, Dotan E, Lubner S, Kumar P, Mulcahy M, Fisher G, Crandall T, Benson A. Paclitaxel With or Without Cixutumumab as Second-Line Treatment of Metastatic Esophageal or Gastroesophageal Junction Cancer: A Randomized Phase II ECOG-ACRIN Trial. The Oncologist 2023, 28: 827-e822. PMID: 37104870, PMCID: PMC10485278, DOI: 10.1093/oncolo/oyad096.Peer-Reviewed Original ResearchConceptsProgression-free survivalSecond-line therapyGastroesophageal junction cancerArm AMetastatic esophagealJunction cancerArm BMedian progression-free survivalRandomized phase II trialMedian overall survivalObjective response rateSecond-line treatmentAdvanced esophageal cancerInsulin-like growth factor 1 receptorPhase II trialStandard of careGrowth factor 1 receptorFactor 1 receptorStable diseaseII trialMetastatic settingPrimary endpointOverall survivalPreclinical evidenceClinical outcomes
2016
Effect of Neoadjuvant Chemoradiotherapy on Pathologic Stage and Survival in Patients with Locally Advanced Esophageal Cancer
L K, B B, A F, RF H, E H, MK G. Effect of Neoadjuvant Chemoradiotherapy on Pathologic Stage and Survival in Patients with Locally Advanced Esophageal Cancer. 2016, 3 DOI: 10.15744/2394-6520.3.105.Peer-Reviewed Original ResearchAdvanced esophageal cancerNeoadjuvant chemoradiotherapyPathologic stageEsophageal cancerChemoradiotherapyPatientsCancer
2009
Phase II trial of docetaxel–irinotecan combination in advanced esophageal cancer
Burtness B, Gibson M, Egleston B, Mehra R, Thomas L, Sipples R, Quintanilla M, Lacy J, Watkins S, Murren JR, Forastiere AA. Phase II trial of docetaxel–irinotecan combination in advanced esophageal cancer. Annals Of Oncology 2009, 20: 1242-1248. PMID: 19429872, PMCID: PMC2699385, DOI: 10.1093/annonc/mdn787.Peer-Reviewed Original ResearchConceptsAdvanced esophageal cancerPartial responseComplete responseEligible patientsEsophageal cancerEastern Cooperative Oncology Group performance statusMetastatic squamous cell carcinomaSafety of docetaxelPhase II trialSquamous cell carcinomaPrincipal toxic effectsAssessable patientsEsophagogastric cancerMeasurable diseaseToxic deathsII trialCN patientsMedian survivalPerformance statusNormal bilirubinPreclinical evidenceMedian timeCell carcinomaMyocardial infarctionTumor assessment
2004
Effect of neoadjuvant chemoradiotherapy on pathologic stage and survival in patients with locally advanced esophageal cancer
Gibson M, Burtness B, Heath E, Heitmiller R, Forastiere A. Effect of neoadjuvant chemoradiotherapy on pathologic stage and survival in patients with locally advanced esophageal cancer. Journal Of Clinical Oncology 2004, 22: 4032-4032. DOI: 10.1200/jco.2004.22.14_suppl.4032.Peer-Reviewed Original ResearchAdvanced esophageal cancerNeoadjuvant chemoradiotherapyPathologic stageEsophageal cancerChemoradiotherapyPatientsCancerEffect of neoadjuvant chemoradiotherapy on pathologic stage and survival in patients with locally advanced esophageal cancer
Gibson M, Burtness B, Heath E, Heitmiller R, Forastiere A. Effect of neoadjuvant chemoradiotherapy on pathologic stage and survival in patients with locally advanced esophageal cancer. Journal Of Clinical Oncology 2004, 22: 4032-4032. DOI: 10.1200/jco.2004.22.90140.4032.Peer-Reviewed Original ResearchAdvanced esophageal cancerNeoadjuvant chemoradiotherapyPathologic stageEsophageal cancerChemoradiotherapyPatientsCancer
2003
Epidermal growth factor receptor, p53 mutation, and pathological response predict survival in patients with locally advanced esophageal cancer treated with preoperative chemoradiotherapy.
Gibson MK, Abraham SC, Wu TT, Burtness B, Heitmiller RF, Heath E, Forastiere A. Epidermal growth factor receptor, p53 mutation, and pathological response predict survival in patients with locally advanced esophageal cancer treated with preoperative chemoradiotherapy. Clinical Cancer Research 2003, 9: 6461-8. PMID: 14695149.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAgedbcl-2-Associated X ProteinCisplatinCombined Modality TherapyDisease-Free SurvivalDNA Mutational AnalysisErbB ReceptorsEsophageal NeoplasmsFemaleFluorouracilGenes, p53HumansImmunohistochemistryMaleMiddle AgedMutationProportional Hazards ModelsProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2Regression AnalysisTime FactorsTreatment OutcomeConceptsAdvanced esophageal cancerOverall survivalComplete responseEsophageal cancerEpidermal growth factor receptorP53 mutationsGrowth factor receptorClinical covariatesCellular markersBetter tumor differentiationPathological complete responseFactor receptorEGF-R expressionBcl-2 expressionInfusional cisplatinDaily radiotherapyMost patientsPoor OSPreoperative chemoradiotherapyPatient agePretreatment tumorOutcome predictorsPredictive factorsBarrett's metaplasiaTumor location
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