2011
Finding subtypes of transcription factor motif pairs with distinct regulatory roles
Bais AS, Kaminski N, Benos PV. Finding subtypes of transcription factor motif pairs with distinct regulatory roles. Nucleic Acids Research 2011, 39: e76-e76. PMID: 21486752, PMCID: PMC3113591, DOI: 10.1093/nar/gkr205.Peer-Reviewed Original ResearchConceptsTF binding sitesTranscription factorsDownstream regulationMotif pairsTF-DNA binding specificityBinding preferencesDNA binding specificityDNA binding preferencesDistinct regulatory rolesDownstream regulatory effectsMultiple regulatory pathwaysDifferent binding preferencesDyad motifDNA sequencesSequence elementsRegulatory pathwaysBinding specificityRegulatory roleDifferential recruitmentBinding sitesMotif discoveryRegulationCofactorMotifDistinct modes
2005
Correlated Evolutionary Pressure at Interacting Transcription Factors and DNA Response Elements Can Guide the Rational Engineering of DNA Binding Specificity
Raviscioni M, Gu P, Sattar M, Cooney AJ, Lichtarge O. Correlated Evolutionary Pressure at Interacting Transcription Factors and DNA Response Elements Can Guide the Rational Engineering of DNA Binding Specificity. Journal Of Molecular Biology 2005, 350: 402-415. PMID: 15946684, DOI: 10.1016/j.jmb.2005.04.054.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological EvolutionComputational BiologyDNADNA Mutational AnalysisDNA-Binding ProteinsEntropyEvolution, MolecularGenomicsHumansModels, GeneticModels, StatisticalMutationNucleic Acid ConformationPhylogenyProtein BindingProtein EngineeringReceptors, Cytoplasmic and NuclearReceptors, EstrogenResponse ElementsSoftwareThermodynamicsTranscription FactorsConceptsDNA binding specificityTranscription factorsBinding specificityEvolutionary importanceEvolutionary pressureResponse elementInteracting Transcription FactorsRational engineeringRelative evolutionary importanceProtein-DNA interfaceProtein-DNA interactionsTranscription factor proteinsDNA response elementsAmino acid residuesNuclear hormone receptorsTranscriptional regulatorsEvolutionary traceImportant residuesGene expressionRecognition codeMolecular mechanismsAcid residuesFactor proteinProtein residuesLRH-1
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply