2018
The Stringent Response Determines the Ability of a Commensal Bacterium to Survive Starvation and to Persist in the Gut
Schofield WB, Zimmermann-Kogadeeva M, Zimmermann M, Barry NA, Goodman AL. The Stringent Response Determines the Ability of a Commensal Bacterium to Survive Starvation and to Persist in the Gut. Cell Host & Microbe 2018, 24: 120-132.e6. PMID: 30008292, PMCID: PMC6086485, DOI: 10.1016/j.chom.2018.06.002.Peer-Reviewed Original ResearchConceptsCarbon starvationStringent responseHuman gut bacterium Bacteroides thetaiotaomicronTricarboxylic acid cycle genesMultiple biosynthetic pathwaysCycle genesCentral metabolismMammalian gutTriggers accumulationBiosynthetic pathwayBacteroides thetaiotaomicronDeficient strainMetabolic regulatorAlpha-ketoglutarate supplementationStarvationAlpha-ketoglutarateC labelingCommensal bacteriaMetabolomic analysisGut microbiomeCommensal bacteriumThetaiotaomicronBacteriaPathwayGut
1987
Repair of plasmid DNA damaged in vitro with cis- or trans-diamminedichloroplatinum(II) in Escherichia coli
Popoff SC, Beck DJ, Rupp WD. Repair of plasmid DNA damaged in vitro with cis- or trans-diamminedichloroplatinum(II) in Escherichia coli. Mutation Research/Fundamental And Molecular Mechanisms Of Mutagenesis 1987, 183: 129-137. PMID: 3547106, DOI: 10.1016/0167-8817(87)90055-1.Peer-Reviewed Original ResearchConceptsSurvival of plasmidsEscherichia coliPlasmid DNATrans-DDPRecA gene productRepair of plasmidsFunctional recA gene productGene functionUvrABC excinucleaseUvrD mutantsGene productsSOS functionsUntreated plasmidsDeficient strainTransformation frequencyTransformation assaysDNAPlasmidPlatinum adductsColiCis-DDPRepair experimentsCellsExcinucleaseMutants
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