2020
Understanding the immunopathogenesis of autoimmune diseases by animal studies using gene modulation: A comprehensive review
Lee K, Ahn B, Cha D, Jang W, Choi E, Park S, Park J, Oh J, Jung D, Park H, Park J, Suh Y, Jin D, Lee S, Jang Y, Yoon T, Park M, Seong Y, Pyo J, Yang S, Kwon Y, Jung H, Lim C, Hong J, Park Y, Choi E, Shin J, Kronbichler A. Understanding the immunopathogenesis of autoimmune diseases by animal studies using gene modulation: A comprehensive review. Autoimmunity Reviews 2020, 19: 102469. PMID: 31918027, DOI: 10.1016/j.autrev.2020.102469.Peer-Reviewed Original ResearchConceptsImmunopathogenesis of autoimmune diseasesSystemic lupus erythematosusAutoimmune diseasesShort interfering ribonucleic acidTumor necrosis factorInflammatory bowel diseaseCytotoxic T-lymphocyte-associated antigen 4T-lymphocyte-associated antigen 4Rheumatoid arthritisTreatment of autoimmune disordersMultiple sclerosisPathogenic inflammatory responsesMolecular basis of autoimmune diseasesMechanisms of autoimmune diseasesAnti-inflammatory cytokinesLevels of interleukinsInadequate immune activationCTLA-4Antigen 4Cytokine antagonistsInvestigate cytokine regulationInterferon-gLupus erythematosusAutoimmune disordersGene modules
2016
Anti-interleukin-17 treatment of psoriasis
Jinna S, Strober B. Anti-interleukin-17 treatment of psoriasis. Journal Of Dermatological Treatment 2016, 27: 311-315. PMID: 26943806, DOI: 10.3109/09546634.2015.1115816.Peer-Reviewed Original ResearchConceptsTreatment of psoriasisPlaque psoriasisTumor necrosis factor alphaIL-17 inhibitorsPhase 3 trialIL-17 receptor subunitNecrosis factor alphaEffective therapeutic targetIL-17Cytokine antagonistsInflammatory dermatosesIL-17RAFactor alphaSafety resultsTherapeutic targetPsoriasisFavorable responseUS populationReceptor subunitsMonoclonal antibodiesDependent pathwayTreatmentTrialsAntibodiesEfficacy
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