2017
B7-DC (PD-L2) costimulation of CD4+ T-helper 1 response via RGMb
Nie X, Chen W, Zhu Y, Huang B, Yu W, Wu Z, Guo S, Zhu Y, Luo L, Wang S, Chen L. B7-DC (PD-L2) costimulation of CD4+ T-helper 1 response via RGMb. Cellular & Molecular Immunology 2017, 15: 888-897. PMID: 28479601, PMCID: PMC6207567, DOI: 10.1038/cmi.2017.17.Peer-Reviewed Original ResearchConceptsRepulsive guidance molecule bT cell responsesB7-DCPD-1T cellsB7-DC/PDCoinhibitory receptor PD-1T helper 1 responseTh2-mediated asthmaSmall airway inflammationReceptor PD-1T cell inhibitionExperimental mouse modelNaive mouse T cellsMouse T cellsAirway inflammationTh1 polarizationTh1 responseDendritic cellsLung pathologyMouse modelCostimulatory functionCostimulatory receptorsCD4Costimulation
1997
Expression of a hypoglycosylated form of CD86 (B7-2) on human T cells with altered binding properties to CD28 and CTLA-4.
Höllsberg P, Scholz C, Anderson DE, Greenfield EA, Kuchroo VK, Freeman GJ, Hafler DA. Expression of a hypoglycosylated form of CD86 (B7-2) on human T cells with altered binding properties to CD28 and CTLA-4. The Journal Of Immunology 1997, 159: 4799-805. PMID: 9366404, DOI: 10.4049/jimmunol.159.10.4799.Peer-Reviewed Original ResearchMeSH KeywordsAbataceptAnimalsAntibodies, MonoclonalAntigens, CDAntigens, DifferentiationB7-2 AntigenCD28 AntigensCD3 ComplexCD4-Positive T-LymphocytesCell Line, TransformedCHO CellsClone CellsCricetinaeCTLA-4 AntigenGlycosylationHumansImmunoconjugatesLymphocyte ActivationMembrane GlycoproteinsProtein BindingT-Lymphocyte SubsetsConceptsPost-translational modificationsCell type-specific post-translational modificationsHuman T cellsDifferent cell typesMajor costimulatory signalChinese hamster ovary cellsHamster ovary cellsCell clonesFusion proteinCostimulatory signalsCell typesT cell activationFunctional significanceOvary cellsBiochemical analysisSurface membraneCostimulatory functionDetectable bindingExpressionT cellsClonesCell activationCTLA-4-Ig fusion proteinCellsCell expression
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