2022
Pharmacological Difference Between Platelet Aggregations in Cardioembolic Stroke Patients with Direct Oral Anticoagulants: A Pilot Study
Nakazaki M, Oka S, Magota H, Kiyose R, Onodera R, Ukai R, Kataoka-Sasaki Y, Sasaki M, Honmou O. Pharmacological Difference Between Platelet Aggregations in Cardioembolic Stroke Patients with Direct Oral Anticoagulants: A Pilot Study. Journal Of Stroke And Cerebrovascular Diseases 2022, 31: 106520. PMID: 35523052, DOI: 10.1016/j.jstrokecerebrovasdis.2022.106520.Peer-Reviewed Original ResearchConceptsDirect oral anticoagulantsPlatelet aggregation testCardioembolic strokePlatelet aggregationFXa inhibitorsOral anticoagulantsStroke patientsPharmacological differencesAdenosine diphosphateAggregation testConcurrent antiplatelet therapyIschemic stroke patientsCardioembolic stroke patientsOnset of symptomsResults Six patientsLight transmission aggregometryFactor Xa inhibitorsAntiplatelet therapySecondary preventionSix patientsAntiplatelet drugsAtrial fibrillationAntiplatelet effectXa inhibitorsDabigatran
2018
Pilot study of novel lab methodology and testing of platelet function in adolescent women with heavy menstrual bleeding
Rocheleau A, Khader A, Ngo A, Boehnlein C, McDavitt C, Lattimore S, Recht M, McCarty O, Haley K. Pilot study of novel lab methodology and testing of platelet function in adolescent women with heavy menstrual bleeding. Pediatric Research 2018, 83: 693-701. PMID: 29166373, PMCID: PMC5902421, DOI: 10.1038/pr.2017.298.Peer-Reviewed Original ResearchConceptsHeavy menstrual bleedingVon Willebrand factorBleeding disordersPlatelet functionCollagen-related peptideAdolescent womenMenstrual bleedingGPIIbIIIa activationAdenosine diphosphateAberrant platelet functionResponse to ADPResponse to multiple agonistsTests of platelet functionPopulation of adolescent womenResponse to calcium ionophorePlatelet function assaysQualitative platelet disordersWhole blood assayPlatelet disordersCalcium ionophoreTRAP-6BD diagnosisMultiple agonistsPlatelet activationPlatelet adhesion
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