2022
EGFR pathway targeting drugs in head and neck cancer in the era of immunotherapy
Kang J, Ko A, Kil S, Mallen-St Clair J, Shin D, Wang M, Srivatsan E. EGFR pathway targeting drugs in head and neck cancer in the era of immunotherapy. Biochimica Et Biophysica Acta (BBA) - Reviews On Cancer 2022, 1878: 188827. PMID: 36309124, DOI: 10.1016/j.bbcan.2022.188827.Peer-Reviewed Original ResearchConceptsEpidermal growth factor receptorReceptor tyrosine kinasesEGFR mAbsNeck cancerEGFR monoclonal antibody cetuximabEra of immunotherapyTreatment of HNCMonoclonal antibody cetuximabTyrosine kinase inhibitorsEGFR variant IIIGrowth factor receptorMetastatic HNCEGFR resistanceImmune cellsClinical trialsOnly FDAAntibody cetuximabGrowth factor ligandsSmall molecule inhibitorsVariant IIIMTOR pathwayCombinatorial treatmentEGFR overexpressionTumor microenvironmentImmunotherapy
2018
Taming the Notch Transcriptional Regulator for Cancer Therapy
Tamagnone L, Zacchigna S, Rehman M. Taming the Notch Transcriptional Regulator for Cancer Therapy. Molecules 2018, 23: 431. PMID: 29462871, PMCID: PMC6017063, DOI: 10.3390/molecules23020431.Peer-Reviewed Original Research
2013
Radio‐responsive tumors exhibit greater intratumoral immune activity than nonresponsive tumors
Gerber S, Lim J, Connolly K, Sedlacek A, Barlow M, Murphy S, Egilmez N, Lord E. Radio‐responsive tumors exhibit greater intratumoral immune activity than nonresponsive tumors. International Journal Of Cancer 2013, 134: 2383-2392. PMID: 24154990, PMCID: PMC3949198, DOI: 10.1002/ijc.28558.Peer-Reviewed Original ResearchConceptsRadiation therapyIL-12Immune cellsImmune responseEffectiveness of RTEfficacy of RTCD8 T cellsIntratumoral immune cellsCytokines IL-12Effectiveness of therapyOutcome of radiotherapyEfficacy of treatmentComplete remissionResponsive tumorsCure rateNonresponsive tumorsT cellsImmune activityAntitumor effectsImmune systemCombinatorial treatmentTumor modelColon adenocarcinomaNonrespondersTumors
2007
Sensory afferents regenerated into dorsal columns after spinal cord injury remain in a chronic pathophysiological state
Tan A, Petruska J, Mendell L, Levine J. Sensory afferents regenerated into dorsal columns after spinal cord injury remain in a chronic pathophysiological state. Experimental Neurology 2007, 206: 257-268. PMID: 17585905, PMCID: PMC3103885, DOI: 10.1016/j.expneurol.2007.05.013.Peer-Reviewed Original ResearchConceptsSpinal cord injuryDorsal columnsChronic pathophysiological stateNerve conditioning lesionConditioning lesionRegenerating axonsCord injurySensory afferentsInjury siteFrequency-following abilityInfusion of antibodiesPathophysiological statesIntrinsic growth stateExperimental spinal cord injuryRegenerating sensory axonsReduced conduction velocityIntrinsic growth capacitySensory axon growthAxonal growthGrowth inhibitory effectSensory neuronsSpinal cordCombinatorial treatmentInhibit axonal growthRepetitive stimuli
2005
Chapter 26 Promoting the Regeneration of Axons within the Central Nervous System
Park J, Strittmatter S. Chapter 26 Promoting the Regeneration of Axons within the Central Nervous System. 2005, 433-xviii. DOI: 10.1016/b978-012738903-5/50027-8.Peer-Reviewed Original ResearchCentral nervous systemSpinal cord injuryNervous systemPeripheral nervous system axonsPNS Schwann cellsPermanent functional deficitsRegeneration of axonsRegenerative capacityLittle functional recoveryFunctional recoveryCell transplantationCord injuryAxonal regenerationFunctional deficitsPNS neuronsCNS gliaSchwann cellsAxon regenerationCombinatorial treatmentTransplantation studiesPromising targetAxonsKinase inhibitionInjuryProteoglycan digestion
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