Environmental fungi target thiol homeostasis to compete with Mycobacterium tuberculosis
Malhotra N, Oh S, Finin P, Medrano J, Andrews J, Goodwin M, Markowitz T, Lack J, Boshoff H, Barry C. Environmental fungi target thiol homeostasis to compete with Mycobacterium tuberculosis. PLOS Biology 2024, 22: e3002852. PMID: 39625876, PMCID: PMC11614215, DOI: 10.1371/journal.pbio.3002852.Peer-Reviewed Original ResearchConceptsBiosynthetic gene clusterGene clusterWhole-genome sequencingSphagnum peat bogsCollection of FungiMycobacterium tuberculosisGenome sequenceThiol stressMycobacterial speciesMtb cellsSphagnum bogFungiA productionCo-CultureInduced expressionThiol homeostasisRNAseqMtbPeat bogsSphagnumBogNatural productsMycothiolGenesVulnerable targets
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