2024
Self‐reported hearing loss is associated with faster cognitive and functional decline but not diagnostic conversion in the ADNI cohort
Miller A, Sharp E, Wang S, Zhao Y, Mecca A, van Dyck C, O'Dell R, Initiative F. Self‐reported hearing loss is associated with faster cognitive and functional decline but not diagnostic conversion in the ADNI cohort. Alzheimer's & Dementia 2024, 20: 7847-7858. PMID: 39324520, PMCID: PMC11567835, DOI: 10.1002/alz.14252.Peer-Reviewed Original ResearchSelf-reported hearing lossFunctional Activities QuestionnaireHearing lossMild cognitive impairmentModifiable risk factorsMild cognitive impairment participantsFunctional declineImpairment diagnosisModified Preclinical Alzheimer Cognitive CompositeRate of functional declineRate of cognitive declinePreclinical Alzheimer Cognitive CompositeRisk factorsCognitive impairmentSignificant longitudinal associationsActivity QuestionnaireLongitudinal associationsAlzheimer's Disease Neuroimaging InitiativeLongitudinal relationshipCognitive compositeCN participantsIncreased riskCognitive declineParticipantsDiagnostic conversion
2023
Association of Pathologic and Volumetric Biomarker Changes With Cognitive Decline in Clinically Normal Adults
Hanseeuw B, Jacobs H, Schultz A, Buckley R, Farrell M, Guehl N, Becker J, Properzi M, Sanchez J, Quiroz Y, Vannini P, Sepulcre J, Yang H, Chhatwal J, Gatchel J, Marshall G, Amariglio R, Papp K, Rentz D, Normandin M, Price J, Healy B, El Fakhri G, Sperling R, Johnson K. Association of Pathologic and Volumetric Biomarker Changes With Cognitive Decline in Clinically Normal Adults. Neurology 2023, 101: e2533-e2544. PMID: 37968130, PMCID: PMC10791053, DOI: 10.1212/wnl.0000000000207962.Peer-Reviewed Original ResearchConceptsAssociated with cognitive declineOlder adultsNon-AD pathologyCognitive declineHippocampal volumeCognitive dataPreclinical Alzheimer Cognitive CompositeInferior temporal tauProspective cohort studyClinically normal older adultsHarvard Aging Brain StudyPittsburgh compound B PET scansOvert cognitive impairmentAnalyzed dataNormal older adultsAging Brain StudyClinically normal adultsLongitudinal associationsAlzheimer's diseaseCohort studyMemory impairmentCognitive compositeCognitive impairmentHippocampal atrophyCognitionAssociation of Novelty-Related Locus Coeruleus Function With Entorhinal Tau Deposition and Memory Decline in Preclinical Alzheimer Disease
Prokopiou P, Engels-Domínguez N, Schultz A, Sepulcre J, Koops E, Papp K, Marshall G, Normandin M, El Fakhri G, Rentz D, Sperling R, Johnson K, Jacobs H. Association of Novelty-Related Locus Coeruleus Function With Entorhinal Tau Deposition and Memory Decline in Preclinical Alzheimer Disease. Neurology 2023, 101: e1206-e1217. PMID: 37491329, PMCID: PMC10516269, DOI: 10.1212/wnl.0000000000207646.Peer-Reviewed Original ResearchConceptsLC activityMemory declineLocus coeruleusCognitive declineEC tauHarvard Aging Brain StudyHuman neuroimaging studiesSteeper memory declineNoradrenergic brainstem nucleiLongitudinal cognitive dataFunctional MRI dataTau depositionAging Brain StudyPreclinical Alzheimer's diseaseTau progressionCortical tau depositionElevated beta-amyloidInterventions promoting resilienceMild cognitive impairmentExecutive dysfunctionExecutive functionNeuroimaging studiesTau spreadingTemporal cortexCognitive composite
2022
The role of cortical microstructural changes on longitudinal accumulation of tau and cognitive decline in at risk older adults
Gagliardi G, Rodriguez‐Vieitez E, Montal V, Sepulcre J, Diez I, Lois C, Hanseeuw B, Schultz A, Properzi M, Papp K, Marshall G, Fortea J, Johnson K, Sperling R, Vannini P. The role of cortical microstructural changes on longitudinal accumulation of tau and cognitive decline in at risk older adults. Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.065744.Peer-Reviewed Original ResearchCortical mean diffusivityCognitive declineOlder adultsCognitively-normal older adultsHarvard Aging Brain StudyAD-related cognitive declinePreclinical Alzheimer Cognitive CompositeCognitively-normal adultsAging Brain StudyAccumulation of tau pathologyAPOE e4 statusBrain microstructural changesCognitive compositeTau accumulationPACC5Gray-matterCognitive AssessmentCognitive impairmentFTP-PETAt-risk individualsAPOE-e4 carriersBrain studiesApo E4E4 statusMean diffusivity
2021
Cortical microstructure is associated with tau burden and predicts cognitive decline and clinical progression in healthy older adults
Rodriguez‐Vieitez E, Montal V, Sepulcre J, Lois C, Hanseeuw B, Vilaplana E, Schultz A, Properzi M, Scott M, Amariglio R, Papp K, Marshall G, Fortea J, Johnson K, Sperling R, Vannini P. Cortical microstructure is associated with tau burden and predicts cognitive decline and clinical progression in healthy older adults. Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.053011.Peer-Reviewed Original ResearchCognitively-normal individualsCortical mean diffusivityCognitive declineMiddle-temporal gyrusHarvard Aging Brain StudyInferior temporal tauPreclinical Alzheimer Cognitive CompositeAging Brain StudyHealthy older adultsRegional cortical thicknessAmyloid-bShort-term cognitive declineDiffusion-weighted imagingBrain gray matterClinical progressionNeuronal injuryC-PiB PETCognitive compositeProgression to MCIGray-matterRegions-of-interestCognitive AssessmentFTP-PETPACC5Cortical thicknessComparing PET and MRI Biomarkers Predicting Cognitive Decline in Preclinical Alzheimer Disease
Mayblyum D, Becker J, Jacobs H, Buckley R, Schultz A, Sepulcre J, Sanchez J, Rubinstein Z, Katz S, Moody K, Vannini P, Papp K, Rentz D, Price J, Sperling R, Johnson K, Hanseeuw B. Comparing PET and MRI Biomarkers Predicting Cognitive Decline in Preclinical Alzheimer Disease. Neurology 2021, 96: e2933-e2943. PMID: 33952655, PMCID: PMC8253562, DOI: 10.1212/wnl.0000000000012108.Peer-Reviewed Original ResearchPreclinical Alzheimer's diseaseCognitive declineHarvard Aging Brain StudyPreclinical Alzheimer Cognitive CompositePrevention trialsAlzheimer's diseaseAging Brain StudyClinically normal adultsPittsburgh compound B (PiB)-PETProspective cohort studyClass II evidenceCompound B (PiB)-PETCognitive compositeIsthmus cingulateIncrease of statistical powerStructural MRICognitive evaluationBackward stepwise regressionEntorhinal cortexHigher amyloidFDG-PETBrain studiesLinear mixed-effects modelsFollow-upCohort study
2020
Gantenerumab in‐depth outcomes
Salloway S, Bateman R, Aschenbrenner A, Benzinger T, Clifford D, Coalier K, Cruchaga C, Fagan A, Farlow M, Goate A, Gordon B, Hassenstab J, Jack C, Koeppe R, McDade E, Mills S, Morris J, Santacruz A, Snyder P, Wang G, Xiong C, Snider B, Mummery C, Surti G, Hannequin D, Wallon D, Berman S, Lah J, Jiménez‐Velazquez I, Roberson E, van Dyck C, Honig L, Sanchez‐Valle R, Brooks W, Gauthier S, Masters C, Galasko D, Brosch J, Hsiung G, Jayadev S, Formaglio M, Masellis M, Clarnette R, Pariente J, Dubois B, Pasquier F, Baudler M, Delmar P, Doody R, Fontoura P, Kerchner G, Team D. Gantenerumab in‐depth outcomes. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.038049.Peer-Reviewed Original ResearchSporadic Alzheimer's diseaseAlzheimer's diseaseCognitive endpointsCDR-SBAmyloid PETBiomarker outcomesMutation carriersSecondary clinical outcomesSecondary efficacy endpointsAutosomal dominant Alzheimer's diseaseClinical trial programClinical Alzheimer's diseaseBeta monoclonal antibodySymptomatic Alzheimer's diseaseAnti-amyloid antibodiesCognitive compositeSymptomatic mutation carriersEfficacy endpointPlacebo groupPrimary outcomeClinical outcomesInitial doseFluid biomarkersTau-PETAmyloid reduction
2019
Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease
Hanseeuw B, Betensky R, Jacobs H, Schultz A, Sepulcre J, Becker J, Cosio D, Farrell M, Quiroz Y, Mormino E, Buckley R, Papp K, Amariglio R, Dewachter I, Ivanoiu A, Huijbers W, Hedden T, Marshall G, Chhatwal J, Rentz D, Sperling R, Johnson K. Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease. JAMA Neurology 2019, 76: 915-924. PMID: 31157827, PMCID: PMC6547132, DOI: 10.1001/jamaneurol.2019.1424.Peer-Reviewed Original ResearchMild cognitive impairmentOlder adultsChoice of outcome measuresPreclinical Alzheimer Cognitive CompositeCognitive impairmentAssociated with cognitive changesProspective cohort studyClinically normal participantsCognitive changesAssociated with subsequent changesMeasure cognitive changeHarvard Aging Brain StudyMeasured 7 yearsPreclinical Alzheimer's diseaseAging Brain StudyPittsburgh compound B PETAlzheimer's diseaseNormal older adultsPrevention trialsOutcome measuresSerial mediation modelCohort studyInclusion criteriaCompound B PETCognitive composite
2017
Functional network integrity presages cognitive decline in preclinical Alzheimer disease
Buckley R, Schultz A, Hedden T, Papp K, Hanseeuw B, Marshall G, Sepulcre J, Smith E, Rentz D, Johnson K, Sperling R, Chhatwal J. Functional network integrity presages cognitive decline in preclinical Alzheimer disease. Neurology 2017, 89: 29-37. PMID: 28592457, PMCID: PMC5496516, DOI: 10.1212/wnl.0000000000004059.Peer-Reviewed Original ResearchConceptsPreclinical Alzheimer Cognitive CompositePreclinical Alzheimer Cognitive Composite scoreClinically normal older adultsNormal older adultsPreclinical Alzheimer's diseaseRs-fcMRICognitive declineBaseline connectivityResting-state functional connectivity MRIControl networkAD-related cognitive declineMeasures of network integrationFunctional connectivity MRIAlzheimer's diseaseNeuropsychological follow-upControl network connectivityOlder adultsFunctional network integrationCompound B PETPittsburgh compound B PETPredictor of ratingsNetwork integrationDorsal attentionCognitive compositeYears of follow-up
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