2025
A Real-World Prospective Multiple Sclerosis Pregnancy Registry in the United States
Houtchens M, Manieri M, Mahlanza T, Pol-Patil J, Klawiter E, Solomon A, Lathi E, Katz J, Ionete C, Morales I, Severson C, Zurawski J, Stankiewicz J, Cabot A, Sadovnick A. A Real-World Prospective Multiple Sclerosis Pregnancy Registry in the United States. Neurology Clinical Practice 2025, 15: e200425. PMID: 39810912, PMCID: PMC11727603, DOI: 10.1212/cpj.0000000000200425.Peer-Reviewed Original ResearchDisease-modifying therapiesHigh-risk pregnanciesPregnancy RegistryPregnancy outcomesMultiple sclerosisConception attemptsTreated with disease-modifying therapiesBaseline Expanded Disability Status ScaleAdverse pregnancy outcomesClinical disease activityCourse of MSExpanded Disability Status ScaleLonger-term developmental outcomesYears of postpartumReproductive-age womenAssisted Reproductive TechnologyDisability Status ScalePeripartum complicationsTime of conceptionObstetric complicationsPostpartum exacerbationPostpartum relapseIntrapartum periodDisease activityProportion of participants
2022
Prevalence, Predictors, and Prognostic Benefits of Remission Achievement in Patients With Systemic Lupus Erythematosus: A Systematic Review
Yang Z, Cheng C, Wang Z, Wang Y, Zhao J, Wang Q, Tian X, Hsieh E, Li M, Zeng X. Prevalence, Predictors, and Prognostic Benefits of Remission Achievement in Patients With Systemic Lupus Erythematosus: A Systematic Review. Arthritis Care & Research 2022, 74: 208-218. PMID: 32986933, DOI: 10.1002/acr.24464.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusPrognostic benefitDisease activityRemission achievementLupus erythematosusRemission statusLower baseline disease activityMajor organ involvementBaseline disease activityClinical disease activityRisk stratification modelPositive serologic resultsDefinition of remissionSLE patientsAdult patientsOrgan involvementDrug withdrawalTreatment adjustmentEmbase databasesRemission definitionsRemissionSerologic activitySerologic resultsPatientsSystematic review
2021
Type I Interferon–Activated STAT4 Regulation of Follicular Helper T Cell–Dependent Cytokine and Immunoglobulin Production in Lupus
Dong X, Antao OQ, Song W, Sanchez GM, Zembrzuski K, Koumpouras F, Lemenze A, Craft J, Weinstein JS. Type I Interferon–Activated STAT4 Regulation of Follicular Helper T Cell–Dependent Cytokine and Immunoglobulin Production in Lupus. Arthritis & Rheumatology 2021, 73: 478-489. PMID: 33512094, PMCID: PMC7914134, DOI: 10.1002/art.41532.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntibody FormationAutoantibodiesB-LymphocytesCase-Control StudiesCytokinesDisease Models, AnimalFemaleHumansImmunoglobulinsInterferon Type IInterferon-gammaInterleukinsLupus Erythematosus, SystemicMaleMice, Inbred MRL lprMiddle AgedRNA-SeqSTAT4 Transcription FactorT Follicular Helper CellsConceptsSystemic lupus erythematosusTfh-like cellsTfh cellsIL-21Human lupusDisease activityCytokine productionSTAT4 activationImmunoglobulin productionPathogenic B cell responsesCourse of lupusClinical disease activityT cell secretionLupus-prone miceHealthy control subjectsCourse of diseaseB cell responsesCytokine interleukin-21Potential therapeutic targetType I IFNB cell maturationSLE patientsPathogenic cytokinesLupus erythematosusInterleukin-21
2016
Increased expression of dedicator-cytokinesis-10, caspase-2 and Synaptotagmin-like 2 is associated with clinical disease activity in multiple sclerosis
Agirrezabal I, Palacios R, Moreno B, Sepulcre J, Abernathy A, Saiz A, Llufriu S, Comabella M, Montalban X, Martinez A, Arteta D, Villoslada P. Increased expression of dedicator-cytokinesis-10, caspase-2 and Synaptotagmin-like 2 is associated with clinical disease activity in multiple sclerosis. Multiple Sclerosis And Demyelinating Disorders 2016, 1: 7. DOI: 10.1186/s40893-016-0009-8.Peer-Reviewed Original ResearchRelapsing-remitting multiple sclerosisCaspase-2Gene OntologyTranscription factorsAnalysis of regulatory networksDisease activityLymphocyte activationAssociated with clinical disease activityGene tripletsRegulatory networksClinical disease activityCohort of MS patientsDNA arraysCo-regulationJASPAR databaseMAPKinase pathwayDEGsStable patientsProspective cohortDisability accumulationHealthy controlsClinical activityMS patientsTranscriptionGenes
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply