2016
Meningitis Caused by Candida Dubliniensis in a Patient with Cirrhosis: A Case Report and Review of the Literature
Yamahiro A, Lau KH, Peaper DR, Villanueva M. Meningitis Caused by Candida Dubliniensis in a Patient with Cirrhosis: A Case Report and Review of the Literature. Mycopathologia 2016, 181: 589-593. PMID: 27038312, DOI: 10.1007/s11046-016-0006-7.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingPatient's mental statusMental statusSubstance use disordersLumbar punctureUse disordersHepatitis C virus-related cirrhosisC virus-related cirrhosisInitial cerebrospinal fluid (CSF) studiesEnd-stage liver diseaseHuman immunodeficiency virus (HIV) infectionBroad-spectrum antibiotic useImprovement of hydrocephalusMultiple lumbar puncturesSterilization of CSFIntravenous antibiotic therapyVirus-related cirrhosisCerebrospinal fluid studiesImmunodeficiency virus infectionInitiation of therapyLiposomal amphotericin BOptimal treatment strategyBroad-spectrum antibioticsCandida dubliniensisRecent chemotherapy
2013
Lessons Learned From Fatal Progressive Multifocal Leukoencephalopathy in a Patient With Multiple Sclerosis Treated With Natalizumab
Boster AL, Nicholas JA, Topalli I, Kisanuki YY, Pei W, Morgan-Followell B, Kirsch CF, Racke MK, Pitt D. Lessons Learned From Fatal Progressive Multifocal Leukoencephalopathy in a Patient With Multiple Sclerosis Treated With Natalizumab. JAMA Neurology 2013, 70: 398-402. PMID: 23338729, DOI: 10.1001/jamaneurol.2013.1960.Peer-Reviewed Original ResearchConceptsProgressive multifocal leukoencephalopathyBrain magnetic resonance imagingMagnetic resonance imagingMultiple sclerosisResonance imagingMultifocal leukoencephalopathyPolymerase chain reaction testingFatal progressive multifocal leukoencephalopathyBenefits of natalizumabInfusions of natalizumabPML risk stratificationAntibody-positive patientsHigh-dose corticosteroidsCerebrospinal fluid studiesHigh clinical suspicionCerebrospinal fluid analysisBrain magnetic resonanceNegative test resultsPolymerase chain reaction resultsSubacute onsetBilateral blindnessClinical suspicionClinical vigilanceCortical demyelinationTherapy duration
1997
The role of serotonin in the pathophysiology and treatment of schizophrenia
Abi-Dargham A, Laruelle M, Aghajanian GK, Charney D, Krystal J. The role of serotonin in the pathophysiology and treatment of schizophrenia. Journal Of Neuropsychiatry 1997, 9: 1-17. PMID: 9017523, DOI: 10.1176/jnp.9.1.1.Peer-Reviewed Original ResearchConceptsRole of serotoninBeneficial effectsSubcortical dopamine activityCerebrospinal fluid studiesCortex of patientsTreatment of schizophreniaBrain tissue analysisSerotonergic hypofunctionDopaminergic antagonistsPharmacological challengeDopamine activityNegative symptomsFluid studiesSchizophreniaPathophysiologySerotoninIllnessTissue analysisTreatmentMore researchAntagonismCompelling evidenceHypofunctionPatientsAntagonist
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