2021
Impact of Chronic Obstructive Pulmonary Disease in Heart Failure With Preserved Ejection Fraction
Jain S, Obeid M, Yenigalla S, Paravathaneni M, Gadela N, Singh G, Kulkarni V, Kondaveety S, Gade K, Lee J, Kulick-Soper C, Sanchez N, Satija V, Hashmath Z, Zamani P, Akers S, Chirinos J. Impact of Chronic Obstructive Pulmonary Disease in Heart Failure With Preserved Ejection Fraction. The American Journal Of Cardiology 2021, 149: 47-56. PMID: 33757785, DOI: 10.1016/j.amjcard.2021.03.009.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal FatAdipose TissueAgedBlack or African AmericanBody CompositionCase-Control StudiesComorbidityFemaleFibrosisHeart FailureHeart VentriclesHumansMagnetic Resonance ImagingMaleMiddle AgedMuscle, SkeletalObesityOrgan SizePericardiumPhenotypePulmonary Disease, Chronic ObstructivePulsatile FlowPulse Wave AnalysisSex DistributionStroke VolumeVascular StiffnessVentricular RemodelingWhite PeopleConceptsChronic obstructive pulmonary diseaseGreater LV massObstructive pulmonary diseaseConcentric LV geometryArterial tonometryAortic stiffnessEjection fractionHeart failurePulmonary diseaseLV massFemale sexHFpEFLV geometryGreater prevalenceBody compositionCardiac structureCardiovascular phenotypesCardiovascular structureParticipantsObesityPatientsTonometryPrevalenceDiseaseMRI
2019
Promoters to Study Vascular Smooth Muscle
Chakraborty R, Saddouk FZ, Carrao AC, Krause DS, Greif DM, Martin KA. Promoters to Study Vascular Smooth Muscle. Arteriosclerosis Thrombosis And Vascular Biology 2019, 39: 603-612. PMID: 30727757, PMCID: PMC6527360, DOI: 10.1161/atvbaha.119.312449.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsCell LineCell LineageCell TransdifferentiationGene Expression RegulationGene Knockout TechniquesGene TargetingHumansMiceMicrofilament ProteinsMuscle ProteinsMuscle, Smooth, VascularMyocytes, Smooth MuscleMyofibroblastsMyosin Heavy ChainsNeovascularization, PathologicNeovascularization, PhysiologicPhenotypePromoter Regions, GeneticRecombinant Fusion ProteinsConceptsSmooth muscle cellsCre driver linesDiversity of phenotypesMuscle cell typesVisceral smooth muscle cellsSMC transdifferentiationActa2 promoterRemarkable plasticityExciting new eraSMC functionCell typesCre linesEmbryonic heartExciting discoveriesPhenotypeMuscle cellsPerivascular adipocytesPromoterVascular smooth muscleNonmuscular cellsExpressionMyeloid cellsCardiovascular phenotypesCellsBlood vessel wall
2015
Pharmacogenomics of estrogens on changes in carotid artery intima-medial thickness and coronary arterial calcification: Kronos Early Estrogen Prevention Study
Miller VM, Jenkins GD, Biernacka JM, Heit JA, Huggins GS, Hodis HN, Budoff MJ, Lobo RA, Taylor HS, Manson JE, Black DM, Naftolin F, Harman SM, de Andrade M. Pharmacogenomics of estrogens on changes in carotid artery intima-medial thickness and coronary arterial calcification: Kronos Early Estrogen Prevention Study. Physiological Genomics 2015, 48: 33-41. PMID: 26508701, PMCID: PMC4757027, DOI: 10.1152/physiolgenomics.00029.2015.Peer-Reviewed Original ResearchConceptsCarotid artery intima-medial thicknessKronos Early Estrogen Prevention StudyMenopausal hormone treatmentCoronary arterial calcificationInnate immunity pathwaysIntima-medial thicknessImmunity pathwaysArterial calcificationPrevention StudySingle nucleotide polymorphismsOral conjugated equine estrogenConjugated equine estrogensTreatment effectsAgatston unitsPlacebo pillsEquine estrogensTreatment outcomesHormonal statusTreatment groupsParticipants 4Hormone treatmentCardiovascular phenotypesPharmacogenomic effectsYr changesEstrogen
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