2003
The effects of fish oil, olive oil, oleic acid and linoleic acid on colorectal neoplastic processes
LLOR X, PONS E, ROCA A, ÀLVAREZ M, MAÑÉ J, FERNÁNDEZ-BAÑARES F, GASSULL MA. The effects of fish oil, olive oil, oleic acid and linoleic acid on colorectal neoplastic processes. Clinical Nutrition 2003, 22: 71-79. PMID: 12553953, DOI: 10.1054/clnu.2002.0627.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisCaco-2 CellsCells, CulturedCyclooxygenase 2Fish OilsGenes, bcl-2HT29 CellsHumansIsoenzymesKeratin-8KeratinsLinoleic AcidMembrane ProteinsMicroscopy, FluorescenceOleic AcidOlive OilPlant OilsProstaglandin-Endoperoxide SynthasesReverse Transcriptase Polymerase Chain ReactionSucrase-Isomaltase ComplexThymidineConceptsColorectal cancer developmentCOX-2Bcl-2 expressionFish oilCancer developmentHT-29 colorectal cancer cellsCell proliferationLinoleic acidColorectal cancer cellsMain dietary sourceFatty acidsLate effectsColorectal carcinogenesisAntineoplastic effectsNeoplastic processInduction of apoptosisEarly downregulationImportant mediatorOlive oilCancer cellsCaco-2Dietary sourcesBcl-2Different fatsApoptosis induction
2002
Inhibition of cholesterol biosynthesis by Δ22-unsaturated phytosterols via competitive inhibition of sterol Δ24-reductase in mammalian cells
FERNÁNDEZ C, SUÁREZ Y, FERRUELO AJ, GÓMEZ-CORONADO D, LASUNCIÓN MA. Inhibition of cholesterol biosynthesis by Δ22-unsaturated phytosterols via competitive inhibition of sterol Δ24-reductase in mammalian cells. Biochemical Journal 2002, 366: 109-119. PMID: 12162789, PMCID: PMC1222779, DOI: 10.1042/bj20011777.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding, CompetitiveCaco-2 CellsCholesterolChromatography, High Pressure LiquidDose-Response Relationship, DrugHL-60 CellsHumansHypolipidemic AgentsKineticsMacrophagesMaleMiceMicrosomes, LiverModels, ChemicalOxidoreductasesPhytosterolsRatsRats, Sprague-DawleyStigmasterolTime FactorsTumor Cells, CulturedConceptsCholesterol biosynthesisCholesterol-lowering actionCholesterol-lowering agentsEffective hypocholesterolaemic agentHL-60 human cell linesRat liver microsomesIntestinal absorptionDietary phytosterolsLiver microsomesHypocholesterolaemic agentsLow intracellular concentrationsCaco-2Inhibition of sterolIncorporation of radioactivityHuman cell linesCell linesInhibitionSaturated side chainIntracellular concentrationCholesterolRelevant concentrationsRadioactivity incorporationPresent studyStrong inhibitionCompetitive inhibition
2000
A Vitamin D3 Analog Induces a G1-Phase Arrest in CaCo-2 Cells by Inhibiting Cdk2 and Cdk6: Roles of Cyclin E, p21Waf1, and p27Kip1**This work was supported by National Institutes of Health Grants DK-39573, CA-36745 (to T.A.B. and M.B.) and P30DK42086 (to T.A.B., Digestive Disease Research Core Center).
Scaglione-Sewell B, Bissonnette M, Skarosi S, Abraham C, Brasitus T. A Vitamin D3 Analog Induces a G1-Phase Arrest in CaCo-2 Cells by Inhibiting Cdk2 and Cdk6: Roles of Cyclin E, p21Waf1, and p27Kip1**This work was supported by National Institutes of Health Grants DK-39573, CA-36745 (to T.A.B. and M.B.) and P30DK42086 (to T.A.B., Digestive Disease Research Core Center). Endocrinology 2000, 141: 3931-3939. DOI: 10.1210/en.141.11.3931.Peer-Reviewed Original ResearchF6-D3Caco-2 cellsActivity of cyclin-dependent kinase 2Azoxymethane model of colon cancerCaco-2Colon cancerModel of colon cancerCyclin EChemopreventive actionTransforming growth factor-bCyclin-dependent kinase 2Human colon adenocarcinoma cell lineAntibody neutralization studiesColon adenocarcinoma cell lineDevelopment of colon adenocarcinomaVitamin D3 analogsHuman colonic epitheliumHuman colon cancerCyclin-dependent kinasesGrowth factor BRats treated with azoxymethaneExpression of cyclin EAdenocarcinoma cell lineAzoxymethane modelCell cycle arrestEffects of glutamine isomers on human (Caco-2) intestinal epithelial proliferation, strain-responsiveness, and differentiation
Murnin M, Kumar A, di Li G, Brown M, Sumpio B, Basson M. Effects of glutamine isomers on human (Caco-2) intestinal epithelial proliferation, strain-responsiveness, and differentiation. Journal Of Gastrointestinal Surgery 2000, 4: 435-442. PMID: 11058864, DOI: 10.1016/s1091-255x(00)80025-6.Peer-Reviewed Original ResearchMeSH KeywordsCaco-2 CellsCell CountCell DifferentiationCell DivisionDietary SupplementsDipeptidyl-Peptidases and Tripeptidyl-PeptidasesEnteral NutritionEnterocytesEnzyme InhibitorsEpithelial CellsFastinggamma-GlutamyltransferaseGastrointestinal MotilityGlutamineHumansIntestinal MucosaIsomerismIsoxazolesPeristalsisStatistics, NonparametricStress, MechanicalConceptsGlutamine supplementationIntestinal epithelial cellsBowel motilityGut mucosaCaco-2 proliferationEpithelial cellsCaco-2L-glutamine supplementationGlutamine metabolismCaco-2 intestinal epithelial cellsIntestinal epithelial proliferationFrequency-dependent mannerHuman Caco-2 intestinal epithelial cellsCaco-2 cellsEnteral feedingL-glutamineHT-29 cellsVillous motilitySelective antagonistEpithelial proliferationLess potencyVivo frequencyMalignant colonocytesHuman colonocytesMaximal stimulation
1996
Regulation of human colonic cell line proliferation and phenotype by sodium butyrate
Basson M, Turowski G, Rashid Z, Hong F, Madri J. Regulation of human colonic cell line proliferation and phenotype by sodium butyrate. Digestive Diseases And Sciences 1996, 41: 1986-1993. PMID: 8888712, DOI: 10.1007/bf02093601.Peer-Reviewed Original ResearchConceptsBrush border enzyme activitiesSerial cell countsCell line proliferationHuman colonic cellsColonic butyrateApparent protective actionColon carcinogenesisMalignant behaviorCell countButyrate effectMucosal differentiationColonic cellsProtective actionSodium butyrateCaco-2Surface expressionCollagen ICollagen IVDietary fiberProliferationRelevant concentrationsCarcinogenesisCultured cellsMotilityMatrix proteins
1992
Characterization of the enterocyte-like brush border cytoskeleton of the C2BBe clones of the human intestinal cell line, Caco-2
Peterson M, Mooseker M. Characterization of the enterocyte-like brush border cytoskeleton of the C2BBe clones of the human intestinal cell line, Caco-2. Journal Of Cell Science 1992, 102: 581-600. PMID: 1506435, DOI: 10.1242/jcs.102.3.581.Peer-Reviewed Original ResearchConceptsMyosin IBB myosin IC2BBe cellsATP-dependent associationBrush border cytoskeletonApical brush borderHeavy chainDomain-specific monoclonal antibodiesBrush borderFilter-grown monolayersCaco-2Cell line Caco-2Human colonic epithelial cellsHuman intestinal cell lineMyosin I.Myosin IIIntestinal cell linePhysical associationLaser scanning confocal microscopyProtein villinCytoskeletonCell culture modelCell typesPattern of distributionVivo structure
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