2013
Use of touch imprint cytology as a simple method to enrich tumor cells for molecular analysis
Dogan S, Becker J, Rekhtman N, Tang L, Nafa K, Ladanyi M, Klimstra D. Use of touch imprint cytology as a simple method to enrich tumor cells for molecular analysis. Cancer Cytopathology 2013, 121: 354-360. PMID: 23576371, DOI: 10.1002/cncy.21292.Peer-Reviewed Original ResearchConceptsTouch imprintsWhole-tumor samplesTumor cellsCarcinoma samplesKRAS exon 2 mutationsNeoplastic cellsTumor-enriched samplesExon 2 mutationsPercentage of carcinoma cellsTouch imprint cytologyKRAS gene mutationsEpithelial tumor cellsFalse-negative resultsImprint cytologyTP slidesNonneoplastic epitheliumTumor DNAMesenchymal stromaMutant to wild-typeGene mutationsLight microscopyNonneoplastic cellsCarcinoma cellsDirect sequencingSanger sequencing
2012
Secondary mutation in a coding mononucleotide tract in MSH6 causes loss of immunoexpression of MSH6 in colorectal carcinomas with MLH1/PMS2 deficiency
Shia J, Zhang L, Shike M, Guo M, Stadler Z, Xiong X, Tang L, Vakiani E, Katabi N, Wang H, Bacares R, Ruggeri J, Boland C, Ladanyi M, Klimstra D. Secondary mutation in a coding mononucleotide tract in MSH6 causes loss of immunoexpression of MSH6 in colorectal carcinomas with MLH1/PMS2 deficiency. Modern Pathology 2012, 26: 131-138. PMID: 22918162, PMCID: PMC3793326, DOI: 10.1038/modpathol.2012.138.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdenosine TriphosphatasesAdolescentAdultAgedAged, 80 and overColorectal NeoplasmsColorectal Neoplasms, Hereditary NonpolyposisDNA Mutational AnalysisDNA Repair EnzymesDNA-Binding ProteinsFemaleHumansImmunohistochemistryMaleMiddle AgedMismatch Repair Endonuclease PMS2MutL Protein Homolog 1Nuclear ProteinsReverse Transcriptase Polymerase Chain ReactionYoung AdultConceptsCoding region microsatellitesColorectal carcinomaMSH6 geneSomatic mutationsReduction of stainingColorectal carcinoma samplesFrameshift mutationChemoradiation therapyDNA mismatch repair proteinsExon 5Immunohistochemical stainingTumor cellsPositive stainingPotential underlying mechanismsCarcinoma samplesDetect mutationsMononucleotide tractsRepair proteinsCarcinomaSecondary mutationsTumorMutationsGenesStaining patternMicrosatellite
2006
Somatic Mutations of ERBB2 Kinase Domain in Gastric, Colorectal, and Breast Carcinomas
Lee J, Soung Y, Seo S, Kim S, Park C, Wang Y, Park K, Nam S, Park W, Kim S, Lee J, Yoo N, Lee S. Somatic Mutations of ERBB2 Kinase Domain in Gastric, Colorectal, and Breast Carcinomas. Clinical Cancer Research 2006, 12: 57-61. PMID: 16397024, DOI: 10.1158/1078-0432.ccr-05-0976.Peer-Reviewed Original ResearchMeSH KeywordsAgedBreast NeoplasmsClass I Phosphatidylinositol 3-KinasesColorectal NeoplasmsDNA Mutational AnalysisErbB ReceptorsFemaleGenes, erbB-2Genes, rasHumansIn Situ Hybridization, FluorescenceMaleMiddle AgedMutationPhosphatidylinositol 3-KinasesPolymerase Chain ReactionPolymorphism, Single-Stranded ConformationalProto-Oncogene Proteins B-rafStomach NeoplasmsConceptsERBB2 kinase domain mutationERBB2 mutationsKinase domain mutationsK-ras mutationsSomatic mutationsHuman cancersK-rasBreast carcinomaERBB2 geneKinase domainPCR-single-strand conformation polymorphism assayErbB2 kinase domainLung adenocarcinomaSingle-strand conformation polymorphism assayDomain mutationsMutation searchMutations of EGFRBreast carcinoma tissuesIn-frame deletion mutationColorectal carcinoma samplesDevelopment of human cancersBRAF geneColorectal carcinomaCarcinoma samplesLung cancer
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