Role of Serotonin on Gene Expression and Physiology in Human Cytotrophoblasts and Placenta
Morris N, Guller S, Tang Z, Zhang Y, Siegman E, Milano K, Rudnick G, Kliman H. Role of Serotonin on Gene Expression and Physiology in Human Cytotrophoblasts and Placenta. Endocrinology 2025, 166: bqaf124. PMID: 40898405, PMCID: PMC12399332, DOI: 10.1210/endocr/bqaf124.Peer-Reviewed Original ResearchConceptsExogenous 5-HTCytotrophoblast nucleiUptake of 5-HTHistone 3Differentiation in vitroMaternal 5-HTTransglutaminase 2Fetal growthIntact placentaPlacental explantsHuman cytotrophoblastsGene expressionSerotonin transporterHuman placentaPlacentaSerotoninRNA expressionWestern blottingCell survivalCell proliferationEscitalopramTrophoblastProtective pathwaysSERTSerotonylation
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