Functional Studies of Plasmodium falciparum Dipeptidyl Aminopeptidase I Using Small Molecule Inhibitors and Active Site Probes
Deu E, Leyva MJ, Albrow VE, Rice MJ, Ellman JA, Bogyo M. Functional Studies of Plasmodium falciparum Dipeptidyl Aminopeptidase I Using Small Molecule Inhibitors and Active Site Probes. Cell Chemical Biology 2010, 17: 808-819. PMID: 20797610, PMCID: PMC2929396, DOI: 10.1016/j.chembiol.2010.06.007.Peer-Reviewed Original ResearchConceptsDipeptidyl aminopeptidasesActivity-based probesSmall molecules resultsNew targetsSmall molecule inhibitorsDipeptidyl aminopeptidase IActive site probesValuable new targetsAminopeptidase IAntimalarial targetImmature trophozoitesMolecule inhibitorsFunctional studiesCovalent inhibitorsParasite growthMalaria parasitesHemoglobin degradationSite probesLow nanomolar concentrationsSpecific inhibitionPlasmodium falciparumNanomolar concentrationsWidespread resistanceInhibitionTarget
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