2024
Interplay between Netrin-1 and Norrin controls arteriovenous zonation of blood–retina barrier integrity
Furtado J, Geraldo L, Leser F, Bartkowiak B, Poulet M, Park H, Robinson M, Pibouin-Fragner L, Eichmann A, Boyé K. Interplay between Netrin-1 and Norrin controls arteriovenous zonation of blood–retina barrier integrity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2408674121. PMID: 39693351, PMCID: PMC11670198, DOI: 10.1073/pnas.2408674121.Peer-Reviewed Original ResearchConceptsBlood-retina barrierBlood-retina barrier integrityGene expressionScRNA-seqEndothelial cellsNetrin-1 receptor UNC5BNetrin-1Cell gene expression programsSingle-cell RNA sequencingDevelopment of retinal diseasesWnt signaling componentsGene expression programsTight junction proteinsMutant endothelial cellsScaffold proteinTranscriptional activityLoss of functionRNA sequencingRetinal arteriolesRetina endothelial cellsRetinal diseasesHomologue 1Expression programsReceptor UNC5BEndothelial subtypes
2001
Male germ cells and photoreceptors, both dependent on close cell–cell interactions, degenerate upon ClC‐2 Cl− channel disruption
Bösl M, Stein V, Hübner C, Zdebik A, Jordt S, Mukhopadhyay A, Davidoff M, Holstein A, Jentsch T. Male germ cells and photoreceptors, both dependent on close cell–cell interactions, degenerate upon ClC‐2 Cl− channel disruption. The EMBO Journal 2001, 20: 1289-1299. PMID: 11250895, PMCID: PMC145530, DOI: 10.1093/emboj/20.6.1289.Peer-Reviewed Original ResearchConceptsClC-2Abnormal Sertoli cellsBlood-retina barrierGerm cellsRetinal pigment epitheliumCl- channelsSevere degenerationMale infertilityPigment epitheliumMale germ cellsClC-2 Cl(-) channelOvert abnormalitiesSeminiferous tubulesNormal outer segmentsSertoli cellsOuter segmentsRetinaCell typesDeathMassive deathCellsPrimary spermatocytesHuman diseasesTubulesCLC Cl(-) channels
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