2020
Mechanisms underlying auditory processing deficits in Fragile X syndrome
McCullagh EA, Rotschafer SE, Auerbach BD, Klug A, Kaczmarek LK, Cramer KS, Kulesza RJ, Razak KA, Lovelace JW, Lu Y, Koch U, Wang Y. Mechanisms underlying auditory processing deficits in Fragile X syndrome. The FASEB Journal 2020, 34: 3501-3518. PMID: 32039504, PMCID: PMC7347277, DOI: 10.1096/fj.201902435r.Peer-Reviewed Original ResearchConceptsAuditory dysfunctionAutism spectrum disorderAuditory brainstem circuitsFragile X syndromeAuditory processing deficitsCommon monogenetic causeNetwork hyperexcitabilityBrainstem circuitsAuditory pathwayAuditory cortexNeuronal plasticityAnimal modelsAuditory hypersensitivitySynaptic developmentHyperacusisMonogenetic causeDysfunctionX syndromeAberrant synaptic developmentBody of dataUnderlying mechanismMultiple mechanismsHuman therapySyndromeProcessing deficits
2016
Epigenetics in Cancer: A Hematological Perspective
Stahl M, Kohrman N, Gore SD, Kim TK, Zeidan AM, Prebet T. Epigenetics in Cancer: A Hematological Perspective. PLOS Genetics 2016, 12: e1006193. PMID: 27723796, PMCID: PMC5065123, DOI: 10.1371/journal.pgen.1006193.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEpigenetic mechanismsEpigenetic regulationNext-generation sequencingEpigenetic therapyCell agingAdvanced phase patientsEpigeneticsGeneration sequencingCancer cellsGenetic aberrationsPhase patientsClinical responseImmune responseHematological perspectiveProduction of drugsMyeloid malignanciesBody of dataCancerOncogenesisSequencingMechanismRegulationFate
2008
The Effect of Emergency Department Crowding on Clinically Oriented Outcomes
Bernstein SL, Aronsky D, Duseja R, Epstein S, Handel D, Hwang U, McCarthy M, McConnell K, Pines JM, Rathlev N, Schafermeyer R, Zwemer F, Schull M, Asplin BR, Medicine E. The Effect of Emergency Department Crowding on Clinically Oriented Outcomes. Academic Emergency Medicine 2008, 16: 1-10. PMID: 19007346, DOI: 10.1111/j.1553-2712.2008.00295.x.Peer-Reviewed Original ResearchConceptsDomains of qualityEmergency departmentED crowdingEffect of EDST-elevation myocardial infarctionTime-sensitive conditionsObjective clinical endpointsEnglish-language literatureEmergency department (ED) crowdingHospital mortalityAcute painCohort studyCase seriesMyocardial infarctionPatient satisfactionSingle institutionClinical endpointsClinical trialsStudy qualityMedical adviceMedicine reportMedical literaturePatientsCareBody of data
2005
Cannabinoids, opioids and eating behavior: The molecular face of hedonism?
Cota D, Tschöp MH, Horvath TL, Levine AS. Cannabinoids, opioids and eating behavior: The molecular face of hedonism? Brain Research Reviews 2005, 51: 85-107. PMID: 16364446, DOI: 10.1016/j.brainresrev.2005.10.004.Peer-Reviewed Original ResearchConceptsOpioid receptor antagonistPrevalence of obesityAnti-obesity drugsAnti-obesity therapiesCentral nervous mechanismsAddictive componentOpioid systemReceptor antagonistEnergy balance controlFood intakeNervous mechanismsAddictive propertiesEnergy homeostasisHealth threatLife expectancyBody of dataRewarding valueAlarming increaseObesityBalance controlHomeostatic componentWestern countriesFunctional interactionHedonic aspectsOpioidsGalanin can attenuate opiate reinforcement and withdrawal
Picciotto MR, Hawes JJ, Brunzell DH, Zachariou V. Galanin can attenuate opiate reinforcement and withdrawal. Neuropeptides 2005, 39: 313-315. PMID: 15944028, DOI: 10.1016/j.npep.2004.12.001.Peer-Reviewed Original ResearchConceptsOpiate reinforcementGalanin receptor agonistAction of opiatesUseful therapeutic agentEndogenous galaninReceptor agonistGalaninKnockout miceBrain areasTransgenic miceBrain regionsBehavioral signsOpiate addictionTherapeutic agentsBody of dataAltered susceptibilityWithdrawalMiceReceptorsAgonistsOpiates
1997
Beneath the emperor's clothes: The body of data in scrapie and CJD
Manuelidis L. Beneath the emperor's clothes: The body of data in scrapie and CJD. Annales De L Institut Pasteur / Actualités 1997, 8: 311-326. DOI: 10.1016/s0924-4204(97)86597-3.Peer-Reviewed Original Research
1990
Ion channel organization of the myelinated fiber
Black J, Kocsis J, Waxman S. Ion channel organization of the myelinated fiber. Trends In Neurosciences 1990, 13: 48-54. PMID: 1690930, DOI: 10.1016/0166-2236(90)90068-l.Peer-Reviewed Original Research
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