2018
B7-H1 maintains the polyclonal T cell response by protecting dendritic cells from cytotoxic T lymphocyte destruction
Chen L, Azuma T, Yu W, Zheng X, Luo L, Chen L. B7-H1 maintains the polyclonal T cell response by protecting dendritic cells from cytotoxic T lymphocyte destruction. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: 3126-3131. PMID: 29507197, PMCID: PMC5866601, DOI: 10.1073/pnas.1722043115.Peer-Reviewed Original ResearchConceptsB7-H1 expressionDendritic cellsT cell responsesB7-H1CTL responsesTumor escapeB7-H1/PDCell responsesSubdominant T-cell responsesPolyclonal T cell responsesCombination cancer immunotherapyDifferent dendritic cellsAdaptive resistanceT lymphocyte destructionAdvanced human cancersMurine tumor modelsSurvival benefitTumor AgDominant AgAntibody blockadeCancer immunotherapyDC functionImmune destructionLymphocyte destructionT lymphocytes
2011
TRAIL/DR5 Plays a Critical Role in NK Cell-Mediated Negative Regulation of Dendritic Cell Cross-Priming of T Cells
Iyori M, Zhang T, Pantel H, Gagne BA, Sentman CL. TRAIL/DR5 Plays a Critical Role in NK Cell-Mediated Negative Regulation of Dendritic Cell Cross-Priming of T Cells. The Journal Of Immunology 2011, 187: 3087-3095. PMID: 21832159, PMCID: PMC3169733, DOI: 10.4049/jimmunol.1003879.Peer-Reviewed Original ResearchConceptsDendritic cellsNK cell interactionsNK cellsTumor AgT cellsNK cell-mediated inhibitionMHC class I AgsCell-mediated inhibitionT cell functionWild-type miceClass I AgCell interactionsTRAIL/DR5 pathwayTRAIL/DR5TRAIL receptor DR5Antitumor immunityLymph nodesCross primingImmune responseEndogenous AgsAg presentationLack expressionDR5 receptorsReceptor DR5Cell function
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