2025
Enhancing reporting and interpretation of surrogate endpoints in rehabilitation randomized controlled trials: a scoping review
Faria C, Scianni A, Manyara A, Taylor R, Ciani O, Polese J. Enhancing reporting and interpretation of surrogate endpoints in rehabilitation randomized controlled trials: a scoping review. Disability And Rehabilitation 2025, ahead-of-print: 1-18. PMID: 40662631, DOI: 10.1080/09638288.2025.2527943.Peer-Reviewed Original ResearchRandomized Controlled TrialsControlled TrialsScoping ReviewPerson-centered outcomesPrimary outcomeEvidence-based careNon-pharmacological interventionsPatient-relevant outcomesHigh-income countriesTransparency of reportingRehabilitation professionalsHealth outcomesChecklist itemsRehabilitation fieldRehabilitationValid itemsTarget outcomesChecklistSurrogate endpointsProtocol registryTrial efficiencyOutcomesMultiple surrogate endpointsScopus databasesTrials
2016
Traditional and new composite endpoints in heart failure clinical trials: facilitating comprehensive efficacy assessments and improving trial efficiency
Anker SD, Schroeder S, Atar D, Bax JJ, Ceconi C, Cowie MR, Crisp A, Dominjon F, Ford I, Ghofrani H, Gropper S, Hindricks G, Hlatky MA, Holcomb R, Honarpour N, Jukema JW, Kim AM, Kunz M, Lefkowitz M, Le Floch C, Landmesser U, McDonagh TA, McMurray JJ, Merkely B, Packer M, Prasad K, Revkin J, Rosano GM, Somaratne R, Stough WG, Voors AA, Ruschitzka F. Traditional and new composite endpoints in heart failure clinical trials: facilitating comprehensive efficacy assessments and improving trial efficiency. European Journal Of Heart Failure 2016, 18: 482-489. PMID: 27071916, DOI: 10.1002/ejhf.516.Peer-Reviewed Original ResearchConceptsHeart failure clinical trialsComposite endpointClinical trialsNew composite endpointHeart failureHeart failure treatmentEffect of therapyHealth system perspectiveOverall treatment effectRepeat hospitalizationPlanned trialsFunctional statusFailure treatmentOutcome eventsPatient burdenEfficacy assessmentPatient experienceNew treatmentsTrialsAdverse effectsEfficiency of trialsEndpointTrial efficiencyTreatment effectsPrimary measure
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply