2009
Thrombin and interleukin-1β decrease HOX gene expression in human first trimester decidual cells: implications for pregnancy loss
Sarno J, Schatz F, Huang SJ, Lockwood C, Taylor HS. Thrombin and interleukin-1β decrease HOX gene expression in human first trimester decidual cells: implications for pregnancy loss. Molecular Human Reproduction 2009, 15: 451-457. PMID: 19389728, PMCID: PMC2722817, DOI: 10.1093/molehr/gap030.Peer-Reviewed Original ResearchConceptsFirst trimester decidual cellsSpontaneous pregnancy lossPregnancy lossIL-1beta treatmentIL-1betaDecidual cellsMedroxyprogesterone acetateHuman first trimester decidual cellsFirst trimester deciduaProduction of cytokinesThrombin treatmentReal-time RT-PCRPregnancy outcomesSurgical treatmentViable pregnancyEarly pregnancySuccessful pregnancyElective terminationTrimester deciduaDefective implantationInflammation resultsInterleukin-1betaReal-time PCRThrombin generationAffymetrix microarray analysis
2005
Thrombin-dependent regulation of matrix metalloproteinase (MMP)-9 levels in human fetal membranes*
Stephenson CD, Lockwood CJ, Ma Y, Guller S. Thrombin-dependent regulation of matrix metalloproteinase (MMP)-9 levels in human fetal membranes*. The Journal Of Maternal-Fetal & Neonatal Medicine 2005, 18: 17-22. PMID: 16105787, DOI: 10.1080/14767050500123632.Peer-Reviewed Original ResearchConceptsMMP-9 levelsMMP-9MMP-1Matrix metalloproteinaseAmniochorionic membranesThrombin receptor agonist peptidePreterm premature ruptureAnti-inflammatory steroidsMajor risk factorMMP-9 expressionThrombin treatmentThrombin receptor agonistPresence of lipopolysaccharideHuman fetal membranesPremature ruptureReceptor agonistRisk factorsSuch hemorrhageDEX treatmentMMP levelsTIMP-1Thrombin receptorTissue inhibitorAgonist peptideFetal membranes
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