2011
MEKK3 Regulates IFN-γ Production in T Cells through the Rac1/2-Dependent MAPK Cascades
Wang X, Zhang F, Chen F, Liu D, Zheng Y, Zhang Y, Dong C, Su B. MEKK3 Regulates IFN-γ Production in T Cells through the Rac1/2-Dependent MAPK Cascades. The Journal Of Immunology 2011, 186: 5791-5800. PMID: 21471448, PMCID: PMC3833674, DOI: 10.4049/jimmunol.1002127.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAminoquinolinesAnimalsCD4-Positive T-LymphocytesCell LineFlow CytometryImmunoblottingInterferon-gammaInterleukin-12Interleukin-18Listeria monocytogenesMAP Kinase Kinase Kinase 3MAP Kinase Signaling SystemMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein KinasesPyrimidinesrac GTP-Binding Proteinsrac1 GTP-Binding ProteinReceptors, Antigen, T-CellConceptsSer/Thr proteinMAPK activationMAPK kinase kinase (MAP3K) familyP38 MAPK activationThr proteinMAPK cascadeKinase familyMAPK signalsConditional knockout miceMEKK3 activationMEKK3 deficiencyMEKK3Cell differentiationTCR stimulationTCR signalsTh2 cell differentiationSpecific roleBacterial infectionsT cellsCellsKnockout miceActivationJNKProductionProtein
2009
Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation
Das J, Ren G, Zhang L, Roberts AI, Zhao X, Bothwell AL, Van Kaer L, Shi Y, Das G. Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation. Journal Of Experimental Medicine 2009, 206: 2407-2416. PMID: 19808254, PMCID: PMC2768861, DOI: 10.1084/jem.20082286.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCytokinesEncephalomyelitis, Autoimmune, ExperimentalGATA3 Transcription FactorInterleukin-6Lymphocyte ActivationMiceMice, KnockoutSTAT4 Transcription FactorSTAT6 Transcription FactorT-Box Domain ProteinsT-Lymphocytes, Helper-InducerTh1 CellsTh2 CellsTransforming Growth Factor betaConceptsTh17 cell differentiationTh17 cellsIL-6Wild-type BALB/c miceBALB/c miceTh17-specific transcription factorsExperimental autoimmune encephalomyelitisT helper cellsCell differentiationGrowth factor betaTh2 cell differentiationGrowth factor βC-STATAutoimmune encephalomyelitisAntiinflammatory cytokinesAutoimmune disordersProinflammatory cytokinesHelper cellsBeta antibodyC miceTh2 cellsFactor betaGATA-3CytokinesMice
2000
T-helper type 2 cell-directed therapy for asthma
Cohn L, Ray A. T-helper type 2 cell-directed therapy for asthma. Pharmacology & Therapeutics 2000, 88: 187-196. PMID: 11150597, DOI: 10.1016/s0163-7258(00)00091-7.BooksConceptsTh2 cell differentiationT helper type 2 cellsNew immunomodulatory strategiesCell-directed therapiesChronic inflammatory diseaseTh2 cell functionType 2 cellsTh cell developmentImmunomodulatory strategiesPathophysiologic abnormalitiesInflammatory diseasesRespiratory tractTh2 cellsImmune responseTraditional therapiesCell differentiationBronchial airwaysAsthmaTherapyCell functionCell effectsCytokinesDiseaseCell developmentMolecular mechanisms
1999
The B7–CD28/CTLA-4 costimulatory pathways in autoimmune disease of the central nervous system
Anderson D, Sharpe A, Hafler D. The B7–CD28/CTLA-4 costimulatory pathways in autoimmune disease of the central nervous system. Current Opinion In Immunology 1999, 11: 677-683. PMID: 10631554, DOI: 10.1016/s0952-7915(99)00036-9.Peer-Reviewed Original ResearchConceptsSelf-reactive T cellsB7-CD28/CTLAAutoimmune diseasesT cellsTh1/Th2 cell differentiationB7-CD28 costimulationHuman autoimmune diseasesCentral nervous systemTh2 cell differentiationCostimulatory pathwayEffector phaseCTLA-4Nervous systemCritical roleDiseaseCTLARecent studiesCell differentiationCellsPast yearPathwayAutoimmunityCD28InitiationCostimulation
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