2002
Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia
Wiemels JL, Leonard BC, Wang Y, Segal MR, Hunger SP, Smith MT, Crouse V, Ma X, Buffler PA, Pine SR. Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 15101-15106. PMID: 12415113, PMCID: PMC137550, DOI: 10.1073/pnas.222481199.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentArtificial Gene FusionBase SequenceChildChild, PreschoolChromosome MappingChromosomes, Human, Pair 1Chromosomes, Human, Pair 19FemaleGene RearrangementHomeodomain ProteinsHumansImmunoglobulin Heavy ChainsInfantMaleMolecular Sequence DataOncogene Proteins, FusionPolymerase Chain ReactionPrecursor Cell Lymphoblastic Leukemia-LymphomaReceptors, Antigen, T-CellRestriction MappingTranslocation, GeneticConceptsAcute lymphoblastic leukemiaLymphoblastic leukemiaTime of birthChildhood acute lymphoblastic leukemiaE2A-PBX1 fusionSubtype of leukemiaAntigen receptor rearrangementNeonatal blood spotsIg heavy chainPediatric patientsTCR rearrangementsPrenatal originReceptor rearrangementPostnatal originCell originMolecular subgroupsLeukemiaNatural historyBlood spotsGuthrie cardsPatientsCell linesChromosomal translocationsPBX1 geneGenomic fusion
1994
Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide.
Wucherpfennig KW, Zhang J, Witek C, Matsui M, Modabber Y, Ota K, Hafler DA. Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. The Journal Of Immunology 1994, 152: 5581-92. PMID: 7514641, DOI: 10.4049/jimmunol.152.11.5581.Peer-Reviewed Original ResearchConceptsT cellsNormal subjectsImmunodominant myelin basic protein peptideMBP-specific T cell linesDR2 haplotypeSpecific T cell clonesTCR beta-chain sequencesReactive T cellsT cell responsesHLA-DR moleculesT cell clonesIdentical TCR sequencesMyelin basic protein peptideIL-2 stimulationT cell linesHuman T cellsAlpha-chain rearrangementMyelin basic proteinMultiple sclerosisBeta chain sequencesTCR rearrangementsPatientsCell responsesTCR alphaTCR sequences
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