2023
Immunogenetic Metabolomics Reveals Key Enzymes That Modulate CAR T-cell Metabolism and Function.
Renauer P, Park J, Bai M, Acosta A, Lee W, Lin G, Zhang Y, Dai X, Wang G, Errami Y, Wu T, Clark P, Ye L, Yang Q, Chen S. Immunogenetic Metabolomics Reveals Key Enzymes That Modulate CAR T-cell Metabolism and Function. Cancer Immunology Research 2023, 11: 1068-1084. PMID: 37253111, PMCID: PMC10527769, DOI: 10.1158/2326-6066.cir-22-0565.Peer-Reviewed Original ResearchConceptsCAR T cellsHER2-specific CAR T cellsT cellsTumor microenvironmentChimeric antigen receptor T cellsT cell-based immunotherapyAntigen receptor T cellsCD19-specific chimeric antigen receptor (CAR) T cellsCAR T-cell therapyCell-based immunotherapyReceptor T cellsT-cell therapyVivo colorectal cancer modelsColorectal cancer modelT cell functionT cell metabolismTumor infiltrationEvasion mechanismsImmunosuppressive metaboliteImmune evasionCancer modelImmunologic analysisCD19-specificUnfavorable tumor microenvironmentPDK1 deficiency
2022
Cutting Edge: mTORC2 Regulates CD8+ Effector and Memory T Cell Differentiation through Serum and Glucocorticoid Kinase 1.
Patel C, Heikamp E, Xu W, Sun I, Oh M, Sun I, Wen J, Tam A, Blosser R, Powell J. Cutting Edge: mTORC2 Regulates CD8+ Effector and Memory T Cell Differentiation through Serum and Glucocorticoid Kinase 1. The Journal Of Immunology 2022, 209: 2287-2291. PMID: 36469844, PMCID: PMC10065985, DOI: 10.4049/jimmunol.2100669.Peer-Reviewed Original ResearchConceptsT cell differentiationT cellsMemory T cell differentiationMemory precursor phenotypeMemory T cellsEfficacy of vaccinesGlucocorticoid-regulated kinase 1Mechanistic targetRapamycin complex 2 (mTORC2) signalingT cell metabolismT cells resultsKinase 1Memory CD8Acute infectionGlucocorticoid kinase 1Tumor immunotherapyCD8Cell differentiationPrecursor phenotypeNuclear translocationPowerful targetSerumRecall capacityEssential regulatorCell metabolism
2021
The Complex Integration of T-cell Metabolism and Immunotherapy
Madden M, Rathmell J. The Complex Integration of T-cell Metabolism and Immunotherapy. Cancer Discovery 2021, 11: 1636-1643. PMID: 33795235, PMCID: PMC8295173, DOI: 10.1158/2159-8290.cd-20-0569.Peer-Reviewed Original ResearchConceptsT cell metabolismT cell functionT cellsImmune-oncology approachesEffector T cellsOxidative metabolismAdoptive cell therapyT cell interactionsT cell fateAntitumor immunityCancer immunotherapyImmune oncologyTumor microenvironmentNormal stimulationCell therapyTumorsAerobic glycolysisMetabolic reprogrammingMetabolic reprogramming eventsImmunotherapyMetabolismCellsTherapyCancerCentral role
2017
Glutathione Primes T Cell Metabolism for Inflammation
Mak TW, Grusdat M, Duncan GS, Dostert C, Nonnenmacher Y, Cox M, Binsfeld C, Hao Z, Brüstle A, Itsumi M, Jäger C, Chen Y, Pinkenburg O, Camara B, Ollert M, Bindslev-Jensen C, Vasiliou V, Gorrini C, Lang PA, Lohoff M, Harris IS, Hiller K, Brenner D. Glutathione Primes T Cell Metabolism for Inflammation. Immunity 2017, 46: 675-689. PMID: 28423341, DOI: 10.1016/j.immuni.2017.03.019.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEncephalomyelitis, Autoimmune, ExperimentalEnergy MetabolismGlutamate-Cysteine LigaseGlutamineGlutathioneGlycolysisImmunoblottingInflammationMice, Inbred C57BLMice, KnockoutNFATC Transcription FactorsProto-Oncogene Proteins c-mycReactive Oxygen SpeciesSignal TransductionT-LymphocytesTOR Serine-Threonine KinasesConceptsReactive oxygen speciesMYC transcription factorsConditional gene targetingT cell-specific ablationGlutamate-cysteine ligaseT cell metabolismRapamycin 1Catalytic subunitMetabolic integrationTranscription factorsGene targetingMetabolic reprogrammingBiosynthetic requirementsUnexpected roleExpression of NFATAntiviral defenseCysteine ligaseCell metabolismGSH pathwayMammalian targetGSH productionMurine TGSH deficiencyOxygen speciesCell effector functions
2015
Lineage relationship of CD8+ T cell subsets is revealed by progressive changes in the epigenetic landscape
Crompton J, Narayanan M, Cuddapah S, Roychoudhuri R, Ji Y, Yang W, Patel S, Sukumar M, Palmer D, Peng W, Wang E, Marincola F, Klebanoff C, Zhao K, Tsang J, Gattinoni L, Restifo N. Lineage relationship of CD8+ T cell subsets is revealed by progressive changes in the epigenetic landscape. Cellular & Molecular Immunology 2015 DOI: 10.1038/cmi.2015.032.Peer-Reviewed Original ResearchHistone modificationsDynamic gene expression programsHistone H3 lysine 4Global gene expression profilingChIP-seq approachH3 lysine 4Gene expression programsT cell differentiationActivation of genesStem cellsGene expression profilingT cell metabolismEpigenetic landscapeLysine 4Expression programsGene expression signaturesEpigenetic mechanismsExpression profilingGene expressionLineage relationshipsCell differentiationT cell ontogenyGenomic landscapeMemory stem cellsExpression signaturesLineage relationship of CD8+ T cell subsets is revealed by progressive changes in the epigenetic landscape
Crompton J, Narayanan M, Cuddapah S, Roychoudhuri R, Ji Y, Yang W, Patel S, Sukumar M, Palmer D, Peng W, Wang E, Marincola F, Klebanoff C, Zhao K, Tsang J, Gattinoni L, Restifo N. Lineage relationship of CD8+ T cell subsets is revealed by progressive changes in the epigenetic landscape. Cellular & Molecular Immunology 2015, 13: 502-513. PMID: 25914936, PMCID: PMC4947817, DOI: 10.1038/cmi.2015.32.Peer-Reviewed Original ResearchConceptsHistone modificationsDynamic gene expression programsHistone H3 lysine 4Global gene expression profilingChIP-seq approachH3 lysine 4Gene expression programsT cell differentiationActivation of genesStem cellsGene expression profilingT cell metabolismEpigenetic landscapeLysine 4Expression programsGene expression signaturesEpigenetic mechanismsExpression profilingGene expressionLineage relationshipsCell differentiationT cell ontogenyGenomic landscapeMemory stem cellsExpression signatures
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply