The Emerging Roles of ATP-Dependent Chromatin Remodeling Complexes in Pancreatic Cancer
Hasan N, Ahuja N. The Emerging Roles of ATP-Dependent Chromatin Remodeling Complexes in Pancreatic Cancer. Cancers 2019, 11: 1859. PMID: 31769422, PMCID: PMC6966483, DOI: 10.3390/cancers11121859.Peer-Reviewed Original ResearchATP-dependent chromatinChromodomain helicase DNA-binding proteinStem cell maintenanceDNA-binding proteinsAberrant chromatin modificationsChromatin modificationsChromatin structureMain subfamiliesCell maintenanceEpigenetic dysregulationChromatinDifferent cancer typesSwitch/Genomic alterationsCritical roleSmall moleculesFrequent mutationsCancer typesChromosomal aberrationsEmerging RoleComplexesLower survival rateAggressive cancerPancreatic cancerMechanistic studiesARID1A‐SIN3A drives retinoic acid‐induced neuroblastoma differentiation by transcriptional repression of TERT
Bui C, Le H, Vu D, Truong K, Nguyen N, Ho M, Truong D. ARID1A‐SIN3A drives retinoic acid‐induced neuroblastoma differentiation by transcriptional repression of TERT. Molecular Carcinogenesis 2019, 58: 1998-2007. PMID: 31365169, DOI: 10.1002/mc.23091.Peer-Reviewed Original ResearchMeSH KeywordsCell DifferentiationCell Line, TumorChild, PreschoolDNA-Binding ProteinsFemaleGene Expression Regulation, NeoplasticHumansInfantInfant, NewbornMaleNeuroblastomaRepressor ProteinsSin3 Histone Deacetylase and Corepressor ComplexTelomeraseTranscription FactorsTranscription, GeneticTretinoinConceptsEpigenetic regulationNB differentiationChromatin Remodeling ComplexKey epigenetic pathwaysChromatin immunoprecipitation-qPCRAT-rich interaction domain 1AImmature differentiation stateExact molecular mechanismsRemodeling complexRepressor complexTranscriptional repressionEpigenetic pathwaysEpigenetic dysregulationDNA bindingMolecular mechanismsMultiple cancer typesTelomerase reverse transcriptase (TERT) promoterQuantitative real-time polymerase chain reactionReverse transcriptase promoterHigh telomerase activityDifferentiation stateSwitch/Polymerase chain reactionTERT expressionDomain 1A
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