2019
ARID1A‐SIN3A drives retinoic acid‐induced neuroblastoma differentiation by transcriptional repression of TERT
Bui C, Le H, Vu D, Truong K, Nguyen N, Ho M, Truong D. ARID1A‐SIN3A drives retinoic acid‐induced neuroblastoma differentiation by transcriptional repression of TERT. Molecular Carcinogenesis 2019, 58: 1998-2007. PMID: 31365169, DOI: 10.1002/mc.23091.Peer-Reviewed Original ResearchMeSH KeywordsCell DifferentiationCell Line, TumorChild, PreschoolDNA-Binding ProteinsFemaleGene Expression Regulation, NeoplasticHumansInfantInfant, NewbornMaleNeuroblastomaRepressor ProteinsSin3 Histone Deacetylase and Corepressor ComplexTelomeraseTranscription FactorsTranscription, GeneticTretinoinConceptsEpigenetic regulationNB differentiationChromatin Remodeling ComplexKey epigenetic pathwaysChromatin immunoprecipitation-qPCRAT-rich interaction domain 1AImmature differentiation stateExact molecular mechanismsRemodeling complexRepressor complexTranscriptional repressionEpigenetic pathwaysEpigenetic dysregulationDNA bindingMolecular mechanismsMultiple cancer typesTelomerase reverse transcriptase (TERT) promoterQuantitative real-time polymerase chain reactionReverse transcriptase promoterHigh telomerase activityDifferentiation stateSwitch/Polymerase chain reactionTERT expressionDomain 1A
2017
Prevalence of promoter mutations in the TERT gene in oral cavity squamous cell carcinoma
Chang K, Wang C, Pickering CR, Huang Y, Tsai C, Tsang N, Kao H, Cheng M, Myers JN. Prevalence of promoter mutations in the TERT gene in oral cavity squamous cell carcinoma. Head & Neck 2017, 39: 1131-1137. PMID: 28230921, DOI: 10.1002/hed.24728.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCarcinoma, Squamous CellCohort StudiesDisease ProgressionDisease-Free SurvivalFemaleGene Expression Regulation, NeoplasticHumansKaplan-Meier EstimateMaleMiddle AgedMouth NeoplasmsMutationPrevalencePromoter Regions, GeneticReal-Time Polymerase Chain ReactionRetrospective StudiesRisk AssessmentStatistics, NonparametricSurvival AnalysisTaiwanTelomeraseConceptsOral cavity squamous cell carcinomaSquamous cell carcinomaTERT promoter mutationsAdjacent normal tissuesPromoter mutationsSomatic TERT promoter mutationsNormal tissuesC228T mutationTelomerase reverse transcriptase (TERT) promoterT mutationSCC tumor tissuesHuman telomerase reverse transcriptase (hTERT) promoterC250T mutationsReverse transcriptase promoterCell carcinomaSCC tumorsC228TTumor tissueTERT activityBetel nutTERT promoterTissuePresent studyMutationsSanger method
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