2021
Endocytosis and the Participation of Glycosaminoglycans Are Important to the Mechanism of Cell Death Induced by β‑Hairpin Antimicrobial Peptides
Buri M, Sperandio L, de Souza K, Antunes F, Rezende M, Melo C, Pinhal M, Barros C, Fernig D, Yates E, Ide J, Smaili S, Riske K, Nader H, dos Santos Tersariol I, Lima M, Judice W, Miranda A, Paredes-Gamero E. Endocytosis and the Participation of Glycosaminoglycans Are Important to the Mechanism of Cell Death Induced by β‑Hairpin Antimicrobial Peptides. ACS Applied Bio Materials 2021, 4: 6488-6501. PMID: 35006908, DOI: 10.1021/acsabm.1c00390.Peer-Reviewed Original ResearchConceptsCell deathAntimicrobial peptidesSecondary structure homologyControl cell deathΒ-hairpin antimicrobial peptidesCommon mechanismCytotoxicity of AMPsStructure homologyMembrane permeabilizationGene expressionMitochondrial potentialCytotoxic modeEndocytosisCell membraneCell tumor modelΒ-hairpin peptidesAMP stimulationPeptidesDynaminHomologyPermeabilizationGlycosaminoglycansMechanismProteinCytotoxicity
1983
Genes for two small cytoplasmic Ro RNAs are adjacent and appear to be single-copy in the human genome
Wolin S, Steitz J. Genes for two small cytoplasmic Ro RNAs are adjacent and appear to be single-copy in the human genome. Cell 1983, 32: 735-744. PMID: 6187471, DOI: 10.1016/0092-8674(83)90059-4.Peer-Reviewed Original ResearchConceptsHuman genomeRo RNAsSecondary structure homologyRNA polymerase IIISmall cytoplasmic ribonucleoproteinsClass III genesGenomic clonesMammalian cellsPolymerase IIIRNA componentStructure homologySingle copyCytoplasmic ribonucleoproteinHY5 RNAMouse cellsHuman cellsHY1Cell extractsGenesRNAGenomeRNAsHY3CellsMY1
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